Prediction of pregnancy-related hypertensive disorders using metabolomics: a systematic review
Carregando...
Data
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Minas Gerais
Descrição
Tipo
Artigo de periódico
Título alternativo
Primeiro orientador
Membros da banca
Resumo
Objective:To determine the accuracy of metabolomics in predicting hypertensive disorders in pregnancy.Design Systematic review of observational studies.Data sources and study eligibility criteria An electronic literature search was performed in June 2019 and February 2022. Two researchers independently selected studies published between 1998 and 2022 on metabolomic techniques applied to predict the condition; subsequently, they extracted data and performed quality assessment. Discrepancies were dealt with a third
reviewer. The primary outcome was pre- eclampsia. Cohort or case–control studies were eligible when maternal
samples were taken before diagnosis of the hypertensive disorder.Study appraisal and synthesis methods Data on study design, maternal characteristics, how hypertension was diagnosed, metabolomics details and metabolites, and accuracy were independently extracted by two authors.Results Among 4613 initially identified studies on metabolomics, 68 were read in full text and 32 articles
were included. Studies were excluded due to duplicated data, study design or lack of identification of metabolites. Metabolomics was applied mainly in the second trimester; the most common technique was liquid- chromatography coupled to mass spectrometry. Among the 122 different metabolites found, there were 23 amino acids and 21 fatty acids. Most of the metabolites were involved with
ammonia recycling; amino acid metabolism; arachidonic acid metabolism; lipid transport, metabolism and peroxidation; fatty acid metabolism; cell signalling; galactose metabolism; nucleotide sugars metabolism; lactose degradation; and glycerolipid metabolism. Only citrate was a common metabolite for prediction of early onset and late- onset pre- eclampsia. Vitamin D was the only metabolite in common for pre- eclampsia and gestational hypertension prediction. Meta- analysis was not performed due to lack of appropriate standardised data.Conclusions and implications: Metabolite signatures may contribute to further insights into the pathogenesis of
pre- eclampsia and support screening tests. Nevertheless, it is mandatory to validate such methods in larger studies
with a heterogeneous population to ascertain the potential for their use in clinical practice.
Abstract
Assunto
Pregnancy, Hypertension, Metabolomics
Palavras-chave
Pregnancy, hypertension, Metabolomics
Citação
Departamento
Curso
Endereço externo
https://pubmed.ncbi.nlm.nih.gov/35470187/