Estudo comparativo do tecido adiposo visceral e o subcutâneo entre indivíduos eutróficos e obesos grau III metabolicamente normais

Abstract

Obesity is associated with the development of cardiovascular diseases and type 2 diabetes mellitus. It has been described that changes that occur in the adipose tissue of obese individuals are implicated in the development of these diseases. However, not all obese individuals develop them. The aim of this study was to compare the expression and secretion of proinflammatory and anti-inflammatory adipokines, expression of matrix metalloproteinases, factors related to insulin action and immunoregulatory factors in subcutaneous and visceral adipose tissue in grade III obese subjects metabolically normal and compare them with normal individuals. There were differences in the expression of leptin, adiponectin, GluT4 between groups, but no difference in the expression of IRS1, CCL2/MCP1, IL6 and TNF tissues or between groups was found. Circulating levels and the expression of IL10 were higher in obese, and subcutaneous adipose tissue. Although the serum level of TGF be similar between groups, the expression and secretion are higher in adipose tissue of obese subjects compared to controls. Expression of MMPs and FOXP3 was higher in visceral and subcutaneous in obese subjects respectively, compared to controls adipose tissue . According to these results it is possible to suggest that profile found in adipose tissue of obese is probably exerting a protective effect on the development of metabolic diseases.