Serum levels of interleukin-33 and its soluble form receptor (sst2) are associated with cognitive performance in patients with schizophrenia
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
Objective: Changes in immune system have been reported in schizophrenia. This study aimed to evaluate the involvement of IL-33, a
member of the IL-1 cytokine family, in schizophrenia and its association with cognitive performance in these patients.Methods: Forty patients with chronic schizophrenia and 40 healthy subjects participated in the study. Serum levels of IL-33 and sST2(soluble form of the IL-33 receptor) were measured using enzyme-linked immunosorbent assay (ELISA). Patients were evaluated with the
Brief Assessment of Cognition in Schizophrenia (BACS) and the Schizophrenia Cognition Rating Scale (SCoRS). Results: Patients with schizophrenia and controls presented similar serum levels of IL-33 and sST2. Levels of both markers were positively correlated with cognitive performance in patients with schizophrenia. Conclusion: We found a significant correlation between IL-33 and sST2 levels and cognition in schizophrenia. Our results might help in the understanding of how immune markers are associated with cognitive impairment in schizophrenia. It remains to be determined whether the association between IL-33/sST2 and cognition is restricted to patients with schizophrenia.
Abstract
Assunto
Esquizofrenia, Interleucina-33, Testes Neuropsicológicos
Palavras-chave
Schizophrenia, Interleukin-33, Cognitive performance
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https://www.sciencedirect.com/science/article/pii/S0010440X16304874?via%3Dihub