Serum levels of interleukin-33 and its soluble form receptor (sst2) are associated with cognitive performance in patients with schizophrenia

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dc.creatorSalvina Mariade Campos-carli
dc.creatorAntônio Lúcio Teixeira
dc.creatorAline Silva Miranda
dc.creatorIngrid Caroline Silva Dias
dc.creatorAmanda de Oliveira
dc.creatorBreno Fiuza Cruz
dc.creatorÉrica Leandro Marciano Vieira
dc.creatorNatalia Pessoa Rocha
dc.creatorIzabela Guimarães Barbosa
dc.creatorJoão Vinícius Salgado
dc.date.accessioned2023-07-17T20:24:14Z
dc.date.accessioned2025-09-08T23:46:58Z
dc.date.available2023-07-17T20:24:14Z
dc.date.issued2017
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.comppsych.2017.01.008
dc.identifier.issn0010440X
dc.identifier.urihttps://hdl.handle.net/1843/56498
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofComprehensive Psychiatry
dc.rightsAcesso Restrito
dc.subjectEsquizofrenia
dc.subjectInterleucina-33
dc.subjectTestes Neuropsicológicos
dc.subject.otherSchizophrenia
dc.subject.otherInterleukin-33
dc.subject.otherCognitive performance
dc.titleSerum levels of interleukin-33 and its soluble form receptor (sst2) are associated with cognitive performance in patients with schizophrenia
dc.typeArtigo de periódico
local.citation.epage101
local.citation.issue2017
local.citation.spage96
local.citation.volume74
local.description.resumoObjective: Changes in immune system have been reported in schizophrenia. This study aimed to evaluate the involvement of IL-33, a member of the IL-1 cytokine family, in schizophrenia and its association with cognitive performance in these patients.Methods: Forty patients with chronic schizophrenia and 40 healthy subjects participated in the study. Serum levels of IL-33 and sST2(soluble form of the IL-33 receptor) were measured using enzyme-linked immunosorbent assay (ELISA). Patients were evaluated with the Brief Assessment of Cognition in Schizophrenia (BACS) and the Schizophrenia Cognition Rating Scale (SCoRS). Results: Patients with schizophrenia and controls presented similar serum levels of IL-33 and sST2. Levels of both markers were positively correlated with cognitive performance in patients with schizophrenia. Conclusion: We found a significant correlation between IL-33 and sST2 levels and cognition in schizophrenia. Our results might help in the understanding of how immune markers are associated with cognitive impairment in schizophrenia. It remains to be determined whether the association between IL-33/sST2 and cognition is restricted to patients with schizophrenia.
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0010440X16304874?via%3Dihub

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