Seizure susceptibility corrupts inferior colliculus acoustic integration
Carregando...
Data
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Minas Gerais
Descrição
Tipo
Artigo de periódico
Título alternativo
Primeiro orientador
Membros da banca
Resumo
Evidence suggests that the pathophysiology associated with epileptic susceptibility
may disturb the functional connectivity of neural circuits and compromise the brain
functions, even when seizures are absent. Although memory impairment is a common
comorbidity found in patients with epilepsy, it is still unclear whether more caudal
structures may play a role in cognitive deficits, particularly in those cases where there
is no evidence of hippocampal sclerosis. This work used a genetically selected rat strain
for seizure susceptibility (Wistar audiogenic rat, WAR) and distinct behavioral (motor
and memory-related tasks) and electrophysiological (inferior colliculus, IC) approaches
to access acoustic primary integrative network properties. The IC neural assemblies’
response was evaluated by auditory transient (focusing on bottom-up processing) and
steady-state evoked response (ASSR, centering on feedforward and feedback forces
over neural circuitry). The results show that WAR displayed no disturbance in motor
performance or hippocampus-dependent memory tasks. Nonetheless, WAR animals
exhibited significative impairment for auditory fear conditioning (AFC) along with no
indicative of IC plastic changes between the pre-conditioning and test phases (ASSR
coherence analysis). Furthermore, WAR’s IC response to transient stimuli presented
shorter latency and higher amplitude compared with Wistar; and the ASSR analysis
showed similar results for WAR and Wistar animals under subthreshold dose of
pentylenetetrazol (pro-convulsive drug) for seizure-induction. Our work demonstrated
alterations at WAR IC neural network processing, which may explain the associated
disturbance on AFC memory.
Abstract
Assunto
Processo estacionario, Fisiopatologia
Palavras-chave
Excitatory-inhibitory imbalance, Wistar audiogenic rat, Cognitive functions, Steady-state evoked response, Transient evoked response
Citação
Curso
Endereço externo
https://www.frontiersin.org/articles/10.3389/fnsys.2019.00063/full