Seizure susceptibility corrupts inferior colliculus acoustic integration

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dc.creatorHyorrana Priscila Pereira Pinto
dc.creatorEric Levi de Oliveira Lucas
dc.creatorVinícius Rezende Carvalho
dc.creatorFlávio Afonso Gonçalves Mourão
dc.creatorLeonardo de Oliveira Guarnieri
dc.creatorEduardo Mazoni Andrade Marçal Mendes
dc.creatorDaniel de Castro Medeiros
dc.creatorMarcio Flavio Dutra Moraes
dc.date.accessioned2023-07-25T17:27:27Z
dc.date.accessioned2025-09-08T22:48:14Z
dc.date.available2023-07-25T17:27:27Z
dc.date.issued2019
dc.identifier.doihttps://doi.org/10.3389/fnsys.2019.00063
dc.identifier.issn1662-5137
dc.identifier.urihttps://hdl.handle.net/1843/56952
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in systems neuroscience
dc.rightsAcesso Aberto
dc.subjectProcesso estacionario
dc.subjectFisiopatologia
dc.subject.otherExcitatory-inhibitory imbalance
dc.subject.otherWistar audiogenic rat
dc.subject.otherCognitive functions
dc.subject.otherSteady-state evoked response
dc.subject.otherTransient evoked response
dc.titleSeizure susceptibility corrupts inferior colliculus acoustic integration
dc.typeArtigo de periódico
local.citation.epage11
local.citation.spage1
local.citation.volume13
local.description.resumoEvidence suggests that the pathophysiology associated with epileptic susceptibility may disturb the functional connectivity of neural circuits and compromise the brain functions, even when seizures are absent. Although memory impairment is a common comorbidity found in patients with epilepsy, it is still unclear whether more caudal structures may play a role in cognitive deficits, particularly in those cases where there is no evidence of hippocampal sclerosis. This work used a genetically selected rat strain for seizure susceptibility (Wistar audiogenic rat, WAR) and distinct behavioral (motor and memory-related tasks) and electrophysiological (inferior colliculus, IC) approaches to access acoustic primary integrative network properties. The IC neural assemblies’ response was evaluated by auditory transient (focusing on bottom-up processing) and steady-state evoked response (ASSR, centering on feedforward and feedback forces over neural circuitry). The results show that WAR displayed no disturbance in motor performance or hippocampus-dependent memory tasks. Nonetheless, WAR animals exhibited significative impairment for auditory fear conditioning (AFC) along with no indicative of IC plastic changes between the pre-conditioning and test phases (ASSR coherence analysis). Furthermore, WAR’s IC response to transient stimuli presented shorter latency and higher amplitude compared with Wistar; and the ASSR analysis showed similar results for WAR and Wistar animals under subthreshold dose of pentylenetetrazol (pro-convulsive drug) for seizure-induction. Our work demonstrated alterations at WAR IC neural network processing, which may explain the associated disturbance on AFC memory.
local.identifier.orcidhttps://orcid.org/0000-0001-9769-9257
local.identifier.orcidhttps://orcid.org/0000-0003-1821-1634
local.identifier.orcidhttps://orcid.org/0000-0002-4519-3585
local.identifier.orcidhttps://orcid.org/0000-0002-2566-2532
local.identifier.orcidhttps://orcid.org/0000-0002-8221-594X
local.identifier.orcidhttps://orcid.org/0000-0003-0243-1309
local.publisher.countryBrasil
local.publisher.departmentENG - DEPARTAMENTO DE ENGENHARIA ELETRÔNICA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/articles/10.3389/fnsys.2019.00063/full

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