Diketopiperazine alkaloids produced by the endophytic fungus Penicillium citrinum and evaluation of their antileishmanial activity
| dc.creator | Luiza Guimarães Tunes | |
| dc.creator | Vivian Nicolau Gonçalves | |
| dc.creator | Daniela Nabak Bueno | |
| dc.creator | Carlos Leomar Zani | |
| dc.creator | Luiz Henrique Rosa | |
| dc.creator | Betania Barros Cota | |
| dc.date.accessioned | 2024-08-07T21:49:48Z | |
| dc.date.accessioned | 2025-09-08T23:50:00Z | |
| dc.date.available | 2024-08-07T21:49:48Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | Fracionamento cromatográfico do extrato antileishmania obtido da fermentação do fungo endofítico Penicillium citrinum, isolado de folhas de Ageratum myriadenia, rendeu três alcalóides de dicetopiperazina; ciclo(L-Pro-L-Leu) (1), ciclo-(L-Pro-L-Phe) (2) e triprostatina B (3). O estruturas desses compostos foram estabelecidas com base em métodos espectroscópicos e comparação com a literatura. Os compostos 1 e 2 foram ativos contra ambas as formas de Leishmania (Leishmania) amazonensis e amastigotas intracelulares de L. (Leishmania) infantum com aproximadamente 50% de inibição do crescimento do parasita a 100 μM. Nenhum dos compostos foi considerado tóxico contra a linha celular de monócitos de leucemia humana (THP-1) a 100 μM. É o primeiro relato sobre isolamento dessas dicetopiperazinas de P. citrinum e seu potencial antileishmania contra L. (L.) infantum. | |
| dc.format.mimetype | ||
| dc.identifier.issn | 19960808 | |
| dc.identifier.uri | https://hdl.handle.net/1843/73338 | |
| dc.language | eng | |
| dc.publisher | Universidade Federal de Minas Gerais | |
| dc.relation.ispartof | African Journal of Microbiology Research | |
| dc.rights | Acesso Aberto | |
| dc.subject | Microbiologia | |
| dc.subject | Fungos | |
| dc.subject | Produtos Biológicos | |
| dc.subject | Leishmaniose | |
| dc.subject.other | Microbiology | |
| dc.subject.other | Fungi | |
| dc.subject.other | Biological Products | |
| dc.subject.other | Leishmaniasis | |
| dc.title | Diketopiperazine alkaloids produced by the endophytic fungus Penicillium citrinum and evaluation of their antileishmanial activity | |
| dc.title.alternative | Alcalóides dicetopiperazínicos produzidos pelo endofítico fungo Penicillium citrinum e avaliação de sua atividade antileishmania | |
| dc.type | Artigo de periódico | |
| local.citation.epage | 567 | |
| local.citation.issue | 28 | |
| local.citation.spage | 562 | |
| local.citation.volume | 13 | |
| local.description.resumo | Chromatographic fractionation of the antileishmanial extract obtained from fermentation of the endophytic fungus Penicillium citrinum, isolated from leaves of Ageratum myriadenia, yielded three diketopiperazine alkaloids; cyclo(L-Pro-L-Leu) (1), cyclo-(L-Pro-L-Phe) (2) and tryprostatin B (3). The structures of these compounds were established on the basis of spectroscopic methods and comparison with the literature. Compounds 1 and 2 were active against both amastigote-like forms of Leishmania (Leishmania) amazonensis and intracelular amastigotes of L. (Leishmania) infantum with approximately 50% of parasite growth inhibition at 100 μM. None of the compounds were considered toxic against human leukemia monocyte cell line (THP-1) at 100 μM. It is the first report about isolation of these diketopiperazines from P. citrinum and their antileishmanial potential against L. (L.) infantum. | |
| local.publisher.country | Brasil | |
| local.publisher.department | ICB - DEPARTAMENTO DE MICROBIOLOGIA | |
| local.publisher.initials | UFMG | |
| local.url.externa | https://academicjournals.org/journal/AJMR/article-full-text-pdf/CB8CF7D62080 |