Prevalence and determinants of depressive symptoms in patients with chagas cardiomyopathy and predominantly preserved cardiac function
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Universidade Federal de Minas Gerais
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Introduction: Chagas cardiomyopathy (ChC) is highly stigmatized, and the presence of depressive symptoms may be a common
feature. However, its determinants remain unclear. Therefore, the present study aimed to verify the prevalence of depression and
the clinical, echocardiographic, functional, and quality of life factors associated with depressive symptoms in patients with ChC and
predominantly preserved cardiac function. Methods: Thirty-five patients with ChC (aged 40 to 60 years, 66% men, NYHA I-III) were
evaluated by echocardiography, cardiopulmonary exercise testing, 6-minute walk test (6MWT), and Mini-Mental State Examination.
Physical activity level was assessed using the Human Activity Profile (HAP) and health-related quality of life was assessed using the
Short-Form Health Survey (SF-36). Depressive symptoms were evaluated using the Beck Depression Inventory. A cutoff point greater
than 9 was indicative of depression. Results: Depression was detected in 13 patients (37%). In the univariate analysis, female sex,
NYHA functional class, body mass index, HAP score, mental summary of SF-36, peak oxygen uptake, and 6MWT distance were
associated with depressive symptoms. The final model showed that only the HAP score (B = -0.533; 95% confidence interval [CI]:
-0.804 to -0.262) and SF-36 mental summary (B = -0.269; 95% CI: -0.386 to -0.153) remained as independent predictors of depressive
symptoms in patients with ChC. Conclusions: Depression was prevalent in patients with ChC and predominantly preserved cardiac
function. Physical activity and mental health were independent risk factors for depressive symptoms.
Abstract
Assunto
Chagas disease., Chagas cardiomyopathy, Depressive Disorder, Exercise Test, Activities of Daily Living, Mental Health
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Chagas disease., Chagas cardiomyopathy, Depressive Disorder, Exercise Test, Activities of Daily Living, Mental Health
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https://doi.org/10.1590/0037-8682-0123-2020