Immune-based therapies for traumatic brain injury: insights from pre-clinical studies
Carregando...
Data
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Minas Gerais
Descrição
Tipo
Artigo de periódico
Título alternativo
Primeiro orientador
Membros da banca
Resumo
Traumatic Brain Injury (TBI) is a major public health problem. It is the leading cause of death and disability, especially among children and young adults. The neurobiology basis underlying TBI pathophysiology remains to be fully revealed. Over the past years, emerging evidence has supported the hypothesis that TBI is an inflammatory based condition, paving the way for the development of potential therapeutic targets. There is no treatment capable to prevent or minimize TBI associated outcomes. Therefore, the search for effective therapies is a priority goal. In this context, animal models have become valuable tools to study molecular and cellular mechanisms involved in TBI pathogenesis as well as novel treatments. Herein, we discuss therapeutic strategies to treat TBI focused on immunomodulatory and/or anti-inflammatory approaches in the pre-clinical setting.
Abstract
Assunto
Cérebro, Ferimentos e lesões, Inflamação, Agentes antiinflamatórios
Palavras-chave
Traumatic brain injury, Inflammation, Treatment, Immunomodulatory agents, Anti-inflammatory, Pathogenesis
Citação
Curso
Endereço externo
https://www.eurekaselect.com/article/99547