Immune-based therapies for traumatic brain injury: insights from pre-clinical studies

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dc.creatorCaroline Amaral Machado
dc.creatorAna Cristina Simões e Silva
dc.creatorAmanda Silva de Miranda
dc.creatorThiago Macedo e Cordeiro
dc.creatorRodrigo Novaes Ferreira
dc.creatorLeonardo Cruz de Souza
dc.creatorAntônio Lúcio Teixeira
dc.creatorAline Silva de Miranda
dc.date.accessioned2022-11-10T19:07:48Z
dc.date.accessioned2025-09-08T23:43:12Z
dc.date.available2022-11-10T19:07:48Z
dc.date.issued2020
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttp://dx.doi.org/10.2174/0929867326666190710173234
dc.identifier.issn1875-533X
dc.identifier.urihttps://hdl.handle.net/1843/47139
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofCurrent Medicinal Chemistry
dc.rightsAcesso Restrito
dc.subjectCérebro
dc.subjectFerimentos e lesões
dc.subjectInflamação
dc.subjectAgentes antiinflamatórios
dc.subject.otherTraumatic brain injury
dc.subject.otherInflammation
dc.subject.otherTreatment
dc.subject.otherImmunomodulatory agents
dc.subject.otherAnti-inflammatory
dc.subject.otherPathogenesis
dc.titleImmune-based therapies for traumatic brain injury: insights from pre-clinical studies
dc.typeArtigo de periódico
local.citation.epage5402
local.citation.issue32
local.citation.spage5374
local.citation.volume27
local.description.resumoTraumatic Brain Injury (TBI) is a major public health problem. It is the leading cause of death and disability, especially among children and young adults. The neurobiology basis underlying TBI pathophysiology remains to be fully revealed. Over the past years, emerging evidence has supported the hypothesis that TBI is an inflammatory based condition, paving the way for the development of potential therapeutic targets. There is no treatment capable to prevent or minimize TBI associated outcomes. Therefore, the search for effective therapies is a priority goal. In this context, animal models have become valuable tools to study molecular and cellular mechanisms involved in TBI pathogenesis as well as novel treatments. Herein, we discuss therapeutic strategies to treat TBI focused on immunomodulatory and/or anti-inflammatory approaches in the pre-clinical setting.
local.identifier.orcidhttps://orcid.org/0000-0003-0586-0483
local.identifier.orcidhttps://orcid.org/0000-0001-9222-3882
local.identifier.orcidhttps://orcid.org/0000-0002-8887-2772
local.identifier.orcidhttps://orcid.org/0000-0003-4933-6309
local.identifier.orcidhttps://orcid.org/0000-0002-5987-8622
local.identifier.orcidhttps://orcid.org/0000-0001-5027-9722
local.identifier.orcidhttps://orcid.org/0000-0002-9621-5422
local.identifier.orcidhttps://orcid.org/0000-0003-2811-7924
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://www.eurekaselect.com/article/99547

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