Development of a bone-targeted pH-sensitive liposomal formulation containing doxorubicin: physicochemical characterization, cytotoxicity and biodistribution evaluation in a mice model of bone metastasis
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Resumo
Despite recent advances in cancer therapy, the treatment of bone tumors remains a major challenge. A possible underlying hypothesis, limitation, and unmet need may be the inability
of therapeutics to penetrate into dense bone mineral, which can lead to poor efficacy and high
toxicity, due to drug uptake in healthy organs. The development of nanostructured formulations
with high affinity for bone could be an interesting approach to overcome these challenges.
Abstract
Assunto
Câncer, Lipossomos, Ossos
Palavras-chave
Hydroxyapatite-targeted formulations, Bisphosphonates, PH-responsive nanostructures, Bone-tumor treatment
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Endereço externo
https://pubmed.ncbi.nlm.nih.gov/27563241/