Development of a bone-targeted pH-sensitive liposomal formulation containing doxorubicin: physicochemical characterization, cytotoxicity and biodistribution evaluation in a mice model of bone metastasis

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dc.creatorDiêgo dos Santos Ferreira
dc.creatorPeter Caravan
dc.creatorLucas Antônio Miranda Ferreira
dc.creatorRicardo José Alves
dc.creatorMônica Cristina de Oliveira
dc.creatorSamilla Dornellas Faria
dc.creatorSávia Caldeira de Araújo Lopes
dc.creatorCláudia Salviano Teixeira
dc.creatorÂngelo Malachias de Souza
dc.creatorRogério Magalhães Paniago
dc.creatorJosé Dias de Souza Filho
dc.creatorBruno Luís de Jesus Pinto Oliveira
dc.creatorAlexander Sávio Ramos Guimarães
dc.date.accessioned2023-04-03T16:42:53Z
dc.date.accessioned2025-09-09T00:36:49Z
dc.date.available2023-04-03T16:42:53Z
dc.date.issued2016
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.2147/IJN.S109966
dc.identifier.issn1178-2013
dc.identifier.urihttps://hdl.handle.net/1843/51493
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Journal of Nanomedicine
dc.rightsAcesso Aberto
dc.subjectCâncer
dc.subjectLipossomos
dc.subjectOssos
dc.subject.otherHydroxyapatite-targeted formulations
dc.subject.otherBisphosphonates
dc.subject.otherPH-responsive nanostructures
dc.subject.otherBone-tumor treatment
dc.titleDevelopment of a bone-targeted pH-sensitive liposomal formulation containing doxorubicin: physicochemical characterization, cytotoxicity and biodistribution evaluation in a mice model of bone metastasis
dc.typeArtigo de periódico
local.citation.epage3751
local.citation.spage3737
local.citation.volume11
local.description.resumoDespite recent advances in cancer therapy, the treatment of bone tumors remains a major challenge. A possible underlying hypothesis, limitation, and unmet need may be the inability of therapeutics to penetrate into dense bone mineral, which can lead to poor efficacy and high toxicity, due to drug uptake in healthy organs. The development of nanostructured formulations with high affinity for bone could be an interesting approach to overcome these challenges.
local.identifier.orcidhttps://orcid.org/0000-0003-1505-7950
local.identifier.orcidhttps://orcid.org/0000-0002-3179-6537
local.identifier.orcidhttps://orcid.org/0000-0003-2474-5536
local.identifier.orcidhttps://orcid.org/0000-0002-8703-4283
local.identifier.orcidhttps://orcid.org/0000-0002-5203-0944
local.identifier.orcidhttps://orcid.org/0000-0002-3656-4882
local.identifier.orcidhttps://orcid.org/0000-0002-7687-4746
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://pubmed.ncbi.nlm.nih.gov/27563241/

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