Cross-talk between obesity and central nervous system: role in cognitive function
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
Obesity is a world health problem. Excess of white adipose tissue (WAT) might lead to development of neurodegenerative disorders. WAT contributes to low-grade inflammation leading to the enhancement of pro-inflammatory adipokines, such as TNF-α, leptin and IL-6, which will lead to a peripheral inflammation that affects central nervous system functioning. Pro-inflammatory adipokines are enhanced in obesity, while anti-inflammatory, such as IL-10 and adiponectin, are reduced. Obesity seems to be related to cognitive decline and the development of neurodegenerative diseases, such as dementia and Alzheimer, through the production of pro-inflammatory adipokines with a consistent reduction of adiponectin and IL-10.
Abstract
Assunto
Obesidade, Inflamação, Leptina, Cérebro, Sistema nervoso central, Cognição
Palavras-chave
Obesity, Inflammation, Leptin, Brain regions, Cognitive performance
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https://crimsonpublishers.com/iod/fulltext/IOD.000551.php