Cross-talk between obesity and central nervous system: role in cognitive function

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dc.creatorRicardo Augusto Leoni de Sousa
dc.creatorDaniel de Almeida Freitas
dc.creatorHércules Ribeiro Leite
dc.date.accessioned2022-07-07T16:45:57Z
dc.date.accessioned2025-09-08T22:48:18Z
dc.date.available2022-07-07T16:45:57Z
dc.date.issued2019-06
dc.format.mimetypepdf
dc.identifier.doihttp://dx.doi.org/10.31031/iod.2019.03.000551
dc.identifier.issn2578-0263
dc.identifier.urihttps://hdl.handle.net/1843/43028
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofIntervention in Obesity and Diabetes
dc.rightsAcesso Aberto
dc.subjectObesidade
dc.subjectInflamação
dc.subjectLeptina
dc.subjectCérebro
dc.subjectSistema nervoso central
dc.subjectCognição
dc.subject.otherObesity
dc.subject.otherInflammation
dc.subject.otherLeptin
dc.subject.otherBrain regions
dc.subject.otherCognitive performance
dc.titleCross-talk between obesity and central nervous system: role in cognitive function
dc.typeArtigo de periódico
local.citation.epage216
local.citation.issue1
local.citation.spage214
local.citation.volume3
local.description.resumoObesity is a world health problem. Excess of white adipose tissue (WAT) might lead to development of neurodegenerative disorders. WAT contributes to low-grade inflammation leading to the enhancement of pro-inflammatory adipokines, such as TNF-α, leptin and IL-6, which will lead to a peripheral inflammation that affects central nervous system functioning. Pro-inflammatory adipokines are enhanced in obesity, while anti-inflammatory, such as IL-10 and adiponectin, are reduced. Obesity seems to be related to cognitive decline and the development of neurodegenerative diseases, such as dementia and Alzheimer, through the production of pro-inflammatory adipokines with a consistent reduction of adiponectin and IL-10.
local.identifier.orcidhttps://orcid.org/ 0000-0003-2622-032X
local.identifier.orcidhttps://orcid.org/0000-0001-8977-8131
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE FISIOTERAPIA
local.publisher.initialsUFMG
local.url.externahttps://crimsonpublishers.com/iod/fulltext/IOD.000551.php

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