EGFR is not amplified in ameloblastoma
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
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Objective: The aim of this study was to investigate alterations in the EGFR gene and its protein expression for a better understanding of the biologic behavior of ameloblastoma.
Study design: Twenty-five samples of ameloblastoma were selected, and dual-color fluorescence in situ hybridization assay was performed. The results of the assay and immunohistochemistry reaction for EGFR and Ki67 were associated with clinicopathologic features and recurrence.
Results: All analyzed cases presented disomy without any gene polysomy or amplification. With regard to EGFR immunoexpression, 3 cases (12%) were considered negative, and 22 (88%) were positive, of which 13 (52%) were weak and 9 (36%) were strong. All samples presented low positivity for Ki67. There was no association between EGFR expression and clinicopathologic features or recurrence (P > .05). In some cases, EGFR immunoexpression was observed without gene amplification.
Conclusions: Ameloblastoma development, progression, or recurrence does not appear to be related to EGFR amplification or polysomy.
Abstract
Assunto
Genes, Ameloblastoma, Proteins
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busca dia 20 do 09 2023 acesso restrito fao clinica assunto Genes, erbB-1 gene EGFR, busca dia 20 do 09 2023 acesso restrito fao clinica assunto Genes, erbB-1 gene EGFR
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https://www.sciencedirect.com/science/article/pii/S2212440318300853?via%3Dihub