EGFR is not amplified in ameloblastoma

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dc.creatorVictor Costa
dc.creatorEduardo Rodrigues Fregnani
dc.creatorFelipe Paiva Fonseca
dc.creatorFábio Abreu Alves
dc.creatorClóvis Antonio Lopes Pinto
dc.creatorEstela Kaminagakura Tango
dc.date.accessioned2023-11-01T20:56:49Z
dc.date.accessioned2025-09-08T23:35:31Z
dc.date.available2023-11-01T20:56:49Z
dc.date.issued2018-05
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2018.02.014
dc.identifier.issn22124403
dc.identifier.urihttps://hdl.handle.net/1843/60449
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
dc.rightsAcesso Restrito
dc.subjectGenes
dc.subjectAmeloblastoma
dc.subjectProteins
dc.subject.otherbusca dia 20 do 09 2023 acesso restrito fao clinica assunto Genes, erbB-1 gene EGFR
dc.subject.otherbusca dia 20 do 09 2023 acesso restrito fao clinica assunto Genes, erbB-1 gene EGFR
dc.titleEGFR is not amplified in ameloblastoma
dc.typeArtigo de periódico
local.citation.epage458
local.citation.issue5
local.citation.spage454
local.citation.volume125
local.description.resumoObjective: The aim of this study was to investigate alterations in the EGFR gene and its protein expression for a better understanding of the biologic behavior of ameloblastoma. Study design: Twenty-five samples of ameloblastoma were selected, and dual-color fluorescence in situ hybridization assay was performed. The results of the assay and immunohistochemistry reaction for EGFR and Ki67 were associated with clinicopathologic features and recurrence. Results: All analyzed cases presented disomy without any gene polysomy or amplification. With regard to EGFR immunoexpression, 3 cases (12%) were considered negative, and 22 (88%) were positive, of which 13 (52%) were weak and 9 (36%) were strong. All samples presented low positivity for Ki67. There was no association between EGFR expression and clinicopathologic features or recurrence (P > .05). In some cases, EGFR immunoexpression was observed without gene amplification. Conclusions: Ameloblastoma development, progression, or recurrence does not appear to be related to EGFR amplification or polysomy.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2212440318300853?via%3Dihub

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