Ginger (Zingiber officinale rosc.) ameliorated metabolic and inflammatory dysfunction induced by high-refined carbohydrate-containing diet in mice
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Resumo
This study aimed to evaluate the effects and the mechanisms of ginger extract intake in the adiposity gain,
metabolic and inflammatory disturbances induced by a high-refined carbohydrate (HC) diet in mice. Ginger extract at doses of
200, 600, and 1800 mg/kg was supplemented in the daily food of obese Balb/c mice during an 8-week experiment. Our
findings indicate that consumption of high doses of ginger extracts prevents the increase of adiposity induced by HC diet,
improves lipid profile, and promotes decrease of inflammatory markers in mice. We showed that ginger addition to HC diet
leads to decrease in the recruitment of cells visualized in vivo in the microvasculature of adipose tissue, decrease of
inflammatory cytokines, and increase of adiponectin serum levels. These results indicate that the consumption of ginger
decreases the negative metabolic consequences induced by HC diet.
Abstract
Assunto
Gengibre, Obesidade, Camundongos
Palavras-chave
Cytokines, Gingerol, Inflammation, Obesity
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Endereço externo
https://www.liebertpub.com/doi/full/10.1089/jmf.2018.0062