Oral and oropharyngeal diffuse large B-Cell lymphoma and high-grade B-Cell lymphoma: a clinicopathologic and prognostic study of 69 cases
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Universidade Federal de Minas Gerais
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Objective: The objective of this study was to describe the clinicopathological, molecular, and prognostic features of oral/oropharyngeal diffuse large B-cell lymphoma (DLBCL) and high-grade B-cell lymphoma.
Study design: All cases were retrieved from 7 Brazilian institutions. Immunohistochemical reactions were performed to confirm the diagnoses and to categorize the tumors. In situ hybridization was used to detect Epstein-Barr virus (EBV) and fluorescence in situ hybridization was used to identify gene rearrangements.
Results: Most cases involved the oral cavity (76.8%). Males and females, with a mean age of 60 years, were evenly affected. Tumors mostly presented as painful swellings. Forty cases represented germinal center B-cell type (58%). Five cases presented double-hit translocation and 3 harbored rearrangement for MYC/BCL2/BCL6. EBV was detected in 3 cases (4.3%). The 5-year overall survival was 44.4%. Female sex, presence of pain and ulcer, microscopic "starry sky pattern" and necrosis, co-expression of c-Myc/Bcl2, and translocation of MYC were associated with a lower survival in univariate analysis (P = .05, P = .01, P = .01, P = .03, P = .05, P = .006, P = .05, respectively).
Conclusion: Patients affected by oral/oropharyngeal DLBCL have a low survival rate. High-grade B-cell lymphoma (17.7%) and EBV-positive DLBCL, not otherwise specified (4.3%) account for a small number of cases.
Abstract
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Lymphoma, large B-Cell, diffuse, Immunohistochemistry, Neoplasms, Survival rate, Epstein-Barr virus infections, Necrosis, Prognosis
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linfomas acesso restrito busca dia 23 do mês 11 novembro ano 2023 assunto Neoplasms fao clínica Oral and oropharyngeal diffuse large b-cell lymphoma and high-grade b-cell lymphoma: a clinicopathologic and prognostic study of 69 cases, neoplasias de cabeça e pescoço título periódico: Oral surgery oral medicine oral pathology oral radiology
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https://www.sciencedirect.com/science/article/pii/S2212440320313328?via%3Dihub