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Oral and oropharyngeal diffuse large B-Cell lymphoma and high-grade B-Cell lymphoma: a clinicopathologic and prognostic study of 69 cases

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dc.creatorCarla Isabelly Rodrigues-Fernandes
dc.creatorDébora Lima Pereira
dc.creatorLuis Fernando Rivero
dc.creatorKelly Tambasco Bezerra
dc.creatorBruno Augusto Benevenuto de Andrade
dc.creatorMário José Romañach
dc.creatorMichele Agostini
dc.creatorJavier Rendón Henao
dc.creatorAmanda de Farias Gabriel
dc.creatorDécio dos Santos Pinto Júnior
dc.creatorManoela Domingues Martins
dc.creatorArnaldo Gonçalves Junior
dc.creatorMateus José de Carvalho Pereira
dc.creatorRicardo Alves Mesquita
dc.creatorRicardo Santiago Gomez
dc.creatorGiovanna Ribeiro Souto
dc.creatorAlan Roger Santos-Silva
dc.creatorPablo Agustin Vargas
dc.creatorMárcio Ajudarte Lopes
dc.creatorOslei Paes de Almeida
dc.creatorFlávia Sirotheau Corrêa Pontes
dc.creatorHélder Antônio Rebelo Pontes
dc.creatorCiro Dantas Soares
dc.creatorRommel Mario Rodríguez Burbano
dc.creatorFelipe Paiva Fonseca
dc.creatorThayná Melo de Lima Morais
dc.creatorGleyson Kleber do Amaral-Silva
dc.creatorMaria Goretti Freire de Carvalho
dc.creatorLucas Lacerda de Souza
dc.creatorFábio Ramôa Pires
dc.creatorTeresa Cristina Ribeiro Bartholomeu dos Santos
dc.date.accessioned2023-12-01T21:32:09Z
dc.date.accessioned2025-09-08T23:11:42Z
dc.date.available2023-12-01T21:32:09Z
dc.date.issued2021-04
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2020.11.005
dc.identifier.issn22124403
dc.identifier.urihttps://hdl.handle.net/1843/61661
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Surgery Oral Medicine Oral Pathology Oral Radiology
dc.rightsAcesso Restrito
dc.subjectLymphoma, large B-Cell, diffuse
dc.subjectImmunohistochemistry
dc.subjectNeoplasms
dc.subjectSurvival rate
dc.subjectEpstein-Barr virus infections
dc.subjectNecrosis
dc.subjectPrognosis
dc.subject.otherlinfomas acesso restrito busca dia 23 do mês 11 novembro ano 2023 assunto Neoplasms fao clínica Oral and oropharyngeal diffuse large b-cell lymphoma and high-grade b-cell lymphoma: a clinicopathologic and prognostic study of 69 cases
dc.subject.otherneoplasias de cabeça e pescoço título periódico: Oral surgery oral medicine oral pathology oral radiology
dc.titleOral and oropharyngeal diffuse large B-Cell lymphoma and high-grade B-Cell lymphoma: a clinicopathologic and prognostic study of 69 cases
dc.typeArtigo de periódico
local.citation.epage462.e4
local.citation.issue4
local.citation.spage452
local.citation.volume131
local.description.resumoObjective: The objective of this study was to describe the clinicopathological, molecular, and prognostic features of oral/oropharyngeal diffuse large B-cell lymphoma (DLBCL) and high-grade B-cell lymphoma. Study design: All cases were retrieved from 7 Brazilian institutions. Immunohistochemical reactions were performed to confirm the diagnoses and to categorize the tumors. In situ hybridization was used to detect Epstein-Barr virus (EBV) and fluorescence in situ hybridization was used to identify gene rearrangements. Results: Most cases involved the oral cavity (76.8%). Males and females, with a mean age of 60 years, were evenly affected. Tumors mostly presented as painful swellings. Forty cases represented germinal center B-cell type (58%). Five cases presented double-hit translocation and 3 harbored rearrangement for MYC/BCL2/BCL6. EBV was detected in 3 cases (4.3%). The 5-year overall survival was 44.4%. Female sex, presence of pain and ulcer, microscopic "starry sky pattern" and necrosis, co-expression of c-Myc/Bcl2, and translocation of MYC were associated with a lower survival in univariate analysis (P = .05, P = .01, P = .01, P = .03, P = .05, P = .006, P = .05, respectively). Conclusion: Patients affected by oral/oropharyngeal DLBCL have a low survival rate. High-grade B-cell lymphoma (17.7%) and EBV-positive DLBCL, not otherwise specified (4.3%) account for a small number of cases.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2212440320313328?via%3Dihub

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