Lower circulating levels of angiotensin-converting enzyme (ace) in patients with schizophrenia
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Resumo
This study aimed at evaluating changes in the renin-angiotensin system (RAS) in patients with schizophrenia in comparison with controls. Plasma levels of angiotensin-converting enzyme (ACE), ACE2, angiotensin (Ang)-(1–7) and Ang II were assessed in 25 patients with schizophrenia and 20 controls. Patients with schizophrenia presented decreased levels of ACE compared to controls [median (25th–75th percentiles) = 434.79 (341.15–524.02) vs. 508.49 (396.34–608.72); p b 0.05]. No significant differences were found regarding ACE2, Ang-(1–7) and Ang II levels. There were no associations between the measured molecules and clinical parame ters. Our results corroborate the hypothesis that the RAS is involved in the pathophysiology of schizophrenia
Abstract
Assunto
Esquizofrenia, Cognição, Sistema Renina-Angiotensina, Angiotensinas, Inibidores da Enzima Conversora de Angiotensina
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Schizophrenia, Cognition, Renin-angiotensin system, Angiotensin, Angiotensin-converting enzyme
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https://www.sciencedirect.com/science/article/pii/S0920996418303566?via%3Dihub