Lower circulating levels of angiotensin-converting enzyme (ace) in patients with schizophrenia

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dc.creatorSatyajitmohite
dc.creatorSalvina m. de Campos-carli
dc.creatorNatalia p. Rocha
dc.creatorShiva Sharma
dc.creatorAline s. Miranda
dc.creatorIzabela Guimarães Barbosa
dc.creatorJoao v. Salgado
dc.creatorAna Cristina Simoes-e-silva
dc.creatorAntonio l. Teixeira
dc.date.accessioned2023-07-17T21:13:52Z
dc.date.accessioned2025-09-09T01:10:01Z
dc.date.available2023-07-17T21:13:52Z
dc.date.issued2018-06-18
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.schres.2018.06.023
dc.identifier.issn09209964
dc.identifier.urihttps://hdl.handle.net/1843/56524
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofSchizophrenia Research
dc.rightsAcesso Restrito
dc.subjectEsquizofrenia
dc.subjectCognição
dc.subjectSistema Renina-Angiotensina
dc.subjectAngiotensinas
dc.subjectInibidores da Enzima Conversora de Angiotensina
dc.subject.otherSchizophrenia
dc.subject.otherCognition
dc.subject.otherRenin-angiotensin system
dc.subject.otherAngiotensin
dc.subject.otherAngiotensin-converting enzyme
dc.titleLower circulating levels of angiotensin-converting enzyme (ace) in patients with schizophrenia
dc.typeArtigo de periódico
local.citation.epage54
local.citation.spage50
local.citation.volume202
local.description.resumoThis study aimed at evaluating changes in the renin-angiotensin system (RAS) in patients with schizophrenia in comparison with controls. Plasma levels of angiotensin-converting enzyme (ACE), ACE2, angiotensin (Ang)-(1–7) and Ang II were assessed in 25 patients with schizophrenia and 20 controls. Patients with schizophrenia presented decreased levels of ACE compared to controls [median (25th–75th percentiles) = 434.79 (341.15–524.02) vs. 508.49 (396.34–608.72); p b 0.05]. No significant differences were found regarding ACE2, Ang-(1–7) and Ang II levels. There were no associations between the measured molecules and clinical parame ters. Our results corroborate the hypothesis that the RAS is involved in the pathophysiology of schizophrenia
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0920996418303566?via%3Dihub

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