Mature T/NK-cell lymphomas of the oral and maxillofacial region: a multi-institutional collaborative study
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Universidade Federal de Minas Gerais
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Membros da banca
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Background: The diagnosis of oral and maxillofacial mature T/NK-cell neoplasms is challenging because of their rarity, morphological heterogeneity and complex immunophenotype with scarce available data describing their clinical and microscopic aspects. Therefore, in this study, we investigated a series of mature T/NK-cell neoplasms affecting this anatomical region and provided an updated literature review.
Methods: Cases diagnosed as mature T/NK-cell lymphomas affecting the oral and maxillofacial region were retrospectively retrieved from six pathology files and their diagnoses were confirmed using haematoxylin and eosin-stained slides, immunohistochemical reactions and in situ hybridization for Epstein-Barr virus (EBV) detection. Patients' clinical data were collected from their pathology forms.
Results: A total of 22 cases were included in this study. Eleven (50%) consisted of extranodal NK/T-cell lymphomas, nasal type; eight (36.4%) were peripheral T-cell lymphomas, NOS; two (9.1%) were adult T-cell leukaemia/lymphomas, and one (4.5%) was an ALK-positive anaplastic large cell lymphoma. Overall, males predominated, with a mean age of 55.7 years. The palate was the most affected site (50%), and tumours usually presented as destructive and painful ulcers. EBV was present in all cases of extranodal NK/T-cell lymphoma nasal type but was absent in the other subtypes.
Conclusion: Among mature T/NK-cell lymphomas of the oral and maxillofacial region, extranodal NK/T-cell lymphoma, nasal type and peripheral T-cell lymphoma, NOS predominated. Older men were the most affected patients, and this heterogeneous group of neoplasms has a very aggressive clinical behaviour.
Abstract
Assunto
Lymphoma, T-cell, Lymphoma, extranodal NK-T-cell, Lymphoma, Lymphoma, non-Hodgkin, Mouth, Oropharynx, Neoplasms, Ulcer, Epstein-Barr virus infections, Leukemia, Lymphoma, large-cell, anaplastic
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Linfoma Journal of oral pathology & medicine esse titulo periodico, 06 Mature t/nk-cell lymphomas of the oral and maxillofacial region: a multi-institutional collaborative study fao clínica, odontopediatria busca dia 13/12/2023 acesso restrito assunto Lymphoma, T-Cell
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https://onlinelibrary.wiley.com/doi/10.1111/jop.13205