Mature T/NK-cell lymphomas of the oral and maxillofacial region: a multi-institutional collaborative study

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dc.creatorManoela Domingues Martins
dc.creatorMônica Simões Israel
dc.creatorNathália de Almeida Freire
dc.creatorMaria Eduarda Zeraik Barreto
dc.creatorCeleste Sánchez-Romero
dc.creatorThamiris de Castro Abrantes
dc.creatorRomán Carlos
dc.creatorLucas Guimarães Abreu
dc.creatorPablo Agustin Vargas
dc.creatorOslei Paes de Almeida
dc.creatorFelipe Paiva Fonseca
dc.creatorMário José Romañach
dc.creatorRicardo Alves Mesquita
dc.creatorBruno Augusto Benevenuto de Andrade
dc.creatorJohn Lennon Silva Cunha
dc.creatorAna Luiza Oliveira Corrêa Roza
dc.creatorMichelle Agostini
dc.creatorAline Corrêa Abrahão
dc.creatorNathalie Henriques Silva Canedo
dc.creatorDenize D'azambuja Ramos
dc.creatorCristiane Bedran Milito
dc.creatorJosé Alcides Almeidade Arruda
dc.creatorFlávia Sirotheau Correa Pontes
dc.creatorHélder Antônio Rebelo Pontes
dc.creatorMarinez Bizarro Barra
dc.creatorVirgilio Gonzales Zanella
dc.creatorMarco Antonio Trevizani Martins
dc.date.accessioned2024-03-04T20:35:20Z
dc.date.accessioned2025-09-09T00:51:36Z
dc.date.available2024-03-04T20:35:20Z
dc.date.issued2021
dc.identifier.doihttps://doi.org/10.1111/jop.13205
dc.identifier.issn09042512
dc.identifier.urihttps://hdl.handle.net/1843/65139
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral pathology & medicine
dc.rightsAcesso Restrito
dc.subjectLymphoma, T-cell
dc.subjectLymphoma, extranodal NK-T-cell
dc.subjectLymphoma
dc.subjectLymphoma, non-Hodgkin
dc.subjectMouth
dc.subjectOropharynx
dc.subjectNeoplasms
dc.subjectUlcer
dc.subjectEpstein-Barr virus infections
dc.subjectLeukemia
dc.subjectLymphoma, large-cell, anaplastic
dc.subject.otherLinfoma Journal of oral pathology & medicine esse titulo periodico
dc.subject.other06 Mature t/nk-cell lymphomas of the oral and maxillofacial region: a multi-institutional collaborative study fao clínica, odontopediatria busca dia 13/12/2023 acesso restrito assunto Lymphoma, T-Cell
dc.titleMature T/NK-cell lymphomas of the oral and maxillofacial region: a multi-institutional collaborative study
dc.typeArtigo de periódico
local.citation.epage557
local.citation.issue6
local.citation.spage548
local.citation.volume50
local.description.resumoBackground: The diagnosis of oral and maxillofacial mature T/NK-cell neoplasms is challenging because of their rarity, morphological heterogeneity and complex immunophenotype with scarce available data describing their clinical and microscopic aspects. Therefore, in this study, we investigated a series of mature T/NK-cell neoplasms affecting this anatomical region and provided an updated literature review. Methods: Cases diagnosed as mature T/NK-cell lymphomas affecting the oral and maxillofacial region were retrospectively retrieved from six pathology files and their diagnoses were confirmed using haematoxylin and eosin-stained slides, immunohistochemical reactions and in situ hybridization for Epstein-Barr virus (EBV) detection. Patients' clinical data were collected from their pathology forms. Results: A total of 22 cases were included in this study. Eleven (50%) consisted of extranodal NK/T-cell lymphomas, nasal type; eight (36.4%) were peripheral T-cell lymphomas, NOS; two (9.1%) were adult T-cell leukaemia/lymphomas, and one (4.5%) was an ALK-positive anaplastic large cell lymphoma. Overall, males predominated, with a mean age of 55.7 years. The palate was the most affected site (50%), and tumours usually presented as destructive and painful ulcers. EBV was present in all cases of extranodal NK/T-cell lymphoma nasal type but was absent in the other subtypes. Conclusion: Among mature T/NK-cell lymphomas of the oral and maxillofacial region, extranodal NK/T-cell lymphoma, nasal type and peripheral T-cell lymphoma, NOS predominated. Older men were the most affected patients, and this heterogeneous group of neoplasms has a very aggressive clinical behaviour.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.13205

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