Msh2 and msh6 genes are methylated in ameloblastoma

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dc.creatorGleyson Kleber do Amaral-Silva
dc.creatorThaís dos Santos Fontes Pereira
dc.creatorCiro Dantas Soares
dc.creatorAna Carolina Prado Ribeiro
dc.creatorAndré Caroli Rocha
dc.creatorRicardo Santiago Gomez
dc.creatorPablo Agustin Vargas
dc.date.accessioned2024-11-27T19:52:50Z
dc.date.accessioned2025-09-09T00:09:28Z
dc.date.available2024-11-27T19:52:50Z
dc.date.issued2020
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2020.04.741
dc.identifier.issn2212-4411
dc.identifier.urihttps://hdl.handle.net/1843/78330
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
dc.rightsAcesso Restrito
dc.subjectMethylation
dc.subjectGenes
dc.subjectDental sac
dc.subjectGene expression
dc.subjectEpigenomics
dc.subjectAmeloblastoma
dc.titleMsh2 and msh6 genes are methylated in ameloblastoma
dc.typeArtigo de periódico
local.citation.epagee272
local.citation.issue3
local.citation.spagee272
local.citation.volume130
local.description.resumoObjective: To analyze the methylation status of the genes MSH2, MSH3, and MSH6 in ameloblastomas. Study Design: Fresh samples of ameloblastoma (group 1, n = 10) and dental fol licles (group 2, n = 10) were digested and their DNA was isolated for quantitative polymerase chain reaction (qPCR). Methylation assessment was performed by EpiTect Methyl II PCR Assays (Qiagen). We also performed immunohistochemical reactions for MSH2, MSH3, and MSH6 in paraffin sections (group 1). The results were digitally quantified in all ameloblastomas. Results: The mean methylation profile of the genes MSH2, MSH3, and MSH6 in ameloblastoma was not statistically different from den tal follicles. However, a negative correlation for MSH2 (r = 0.7455; P = .0174) and MSH6 (r = 0.8552; P = .0016) protein expression with the methylation profile was found in ameloblas toma. Conclusion: Although the methylation profile of the genes in ameloblastoma was not different from dental follicles, our study shows that epigenetic events are potential regulators of MSH2 and MSH6 protein expression in ameloblastomas.
local.identifier.orcidhttps://orcid.org/0000-0002-6644-3264
local.identifier.orcidhttps://orcid.org/0000-0002-6861-6640
local.identifier.orcidhttps://orcid.org/0000-0002-0127-7998
local.identifier.orcidhttps://orcid.org/0000-0003-0070-0640
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.identifier.orcidhttps://orcid.org/0000-0003-1840-4911
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/abs/pii/S2212440320308956

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