Radiosensitizing effects of citrate-coated cobalt and nickel ferrite nanoparticles on breast cancer cells
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Resumo
Evaluation of the biocompatibility and radiosensitizer potential of citrate-coated cobalt (cit-CF) and nickel (cit-NF) ferrite nanoparticles (NPs). Materials & methods: Normal fibroblast and breast cancer cells were treated with different concentrations of citrate-coated ferrite NPs (cit-NPs) and irradiated with a cobalt-60 source at doses of 1 and 3 Gy. After 24 h, cell metabolism, morphology alterations and nanoparticle uptake were evaluated. Results: Cit-CF and cit-NF NPs showed no toxicity to normal cells up to 250 and 100 μg.ml-1, respectively. Combination of cit-NP and ionizing radiation resulted in up to fivefold increase in the radiation therapeutic efficacy against breast cancer cells. Conclusion: Cit-CF and cit-NF NPs are suitable candidates for application as breast cancer cell radiosensitizers.
Abstract
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Biocompatibilidade, Câncer de mama, Nanobiotecnologia
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Biocompatibility, Breast cancer, Nanobiotechnology, Nanostructured magnetic ferrites, Radiosensitizers
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https://www.tandfonline.com/doi/full/10.2217/nnm-2020-0313