Radiosensitizing effects of citrate-coated cobalt and nickel ferrite nanoparticles on breast cancer cells

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dc.creatorDaniele Alves Fagundes
dc.creatorLiliam Viana Leonel
dc.creatorLuis Eugenio Fernandez Outon
dc.creatorJose Domingos Ardisson
dc.creatorRaquel Gouvêa dos Santos
dc.date.accessioned2025-02-24T18:23:54Z
dc.date.accessioned2025-09-08T23:47:05Z
dc.date.available2025-02-24T18:23:54Z
dc.date.issued2020
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.2217/nnm-2020-0313
dc.identifier.issn1748-6963
dc.identifier.urihttps://hdl.handle.net/1843/80363
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofNanomedicine
dc.rightsAcesso Restrito
dc.subjectBiocompatibilidade
dc.subjectCâncer de mama
dc.subjectNanobiotecnologia
dc.subject.otherBiocompatibility
dc.subject.otherBreast cancer
dc.subject.otherNanobiotechnology
dc.subject.otherNanostructured magnetic ferrites
dc.subject.otherRadiosensitizers
dc.titleRadiosensitizing effects of citrate-coated cobalt and nickel ferrite nanoparticles on breast cancer cells
dc.typeArtigo de periódico
local.citation.epage2836
local.citation.issue29
local.citation.spage2823
local.citation.volume15
local.description.resumoEvaluation of the biocompatibility and radiosensitizer potential of citrate-coated cobalt (cit-CF) and nickel (cit-NF) ferrite nanoparticles (NPs). Materials & methods: Normal fibroblast and breast cancer cells were treated with different concentrations of citrate-coated ferrite NPs (cit-NPs) and irradiated with a cobalt-60 source at doses of 1 and 3 Gy. After 24 h, cell metabolism, morphology alterations and nanoparticle uptake were evaluated. Results: Cit-CF and cit-NF NPs showed no toxicity to normal cells up to 250 and 100 μg.ml-1, respectively. Combination of cit-NP and ionizing radiation resulted in up to fivefold increase in the radiation therapeutic efficacy against breast cancer cells. Conclusion: Cit-CF and cit-NF NPs are suitable candidates for application as breast cancer cell radiosensitizers.
local.identifier.orcidhttps://orcid.org/0000-0003-2853-7638
local.identifier.orcidhttps://orcid.org/0000-0003-4254-1166
local.identifier.orcidhttps://orcid.org/0000-0003-3264-337X
local.identifier.orcidhttps://orcid.org/0000-0002-5615-3482
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.tandfonline.com/doi/full/10.2217/nnm-2020-0313

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