Novel self-nanoemulsifying drug-delivery system enhances antileukemic properties of all- trans retinoic acid
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
All-trans retinoic acid (ATRA) shows erratic oral bioavailability when administered orally against leukemia, which can be solved through its incorporation in self-nanoemulsifying drug-delivery systems (SEDDS). The SEDDS developed contained a hydrophobic ion pair between benzathine (BZT) and ATRA and was enriched with tocotrienols by the input of a palm oil tocotrienol rich fraction (TRF) in its composition. Results: SEDDS-TRF-ATRA-BZT allowed the formation of emulsions with nanometric size that retained ATRA within their core after dispersion. Pharmacokinetic parameters after oral administration of SEDDS-TRF-ATRA-BZT in mice were improved compared with what was seen for an ATRA solution. Moreover, SEDDS-TRF-ATRA-BZT had improved activity against HL-60 cells compared with SEDDS without TRF.
Abstract
Assunto
Leucemia, Câncer
Palavras-chave
Self-nanoemulsifying drug delivery system, all-trans retinoic acid, Acute promyelocytic leukaemia, tocotrienols, Hydrophobic ion pair
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Endereço externo
https://www-futuremedicine-com.ez27.periodicos.capes.gov.br/doi/epub/10.2217/nnm-2020-0061