Novel self-nanoemulsifying drug-delivery system enhances antileukemic properties of all- trans retinoic acid

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dc.creatorGabriel Silva Marques Borges
dc.creatorMaria Irene Yoshida
dc.creatorElaine Maria de Souza Fagundes
dc.creatorChristian Fernandes
dc.creatorLucas Antônio Miranda Ferreira
dc.creatorMicael de Oliveira Ferencs
dc.creatorCristina de Mello Gomide Loures
dc.creatorMostafa Abdellatif Abdelsalam Abdelrheem
dc.creatorFernanda Cristina Gontijo Evangelista
dc.creatorCamila Campos Sales
dc.creatorPedro Henrique Reis da Silva
dc.creatorRenata Barbosa de Oliveira
dc.creatorÂngelo Malachias de Souza
dc.creatorAdriano de Paula Sabino
dc.date.accessioned2023-05-30T12:20:21Z
dc.date.accessioned2025-09-09T00:04:43Z
dc.date.available2023-05-30T12:20:21Z
dc.date.issued2020
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi-org.ez27.periodicos.capes.gov.br/10.2217/nnm-2020-0061
dc.identifier.issn1748-6963
dc.identifier.urihttps://hdl.handle.net/1843/54163
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofNanomedicine
dc.rightsAcesso Restrito
dc.subjectLeucemia
dc.subjectCâncer
dc.subject.otherSelf-nanoemulsifying drug delivery system
dc.subject.otherall-trans retinoic acid
dc.subject.otherAcute promyelocytic leukaemia
dc.subject.othertocotrienols
dc.subject.otherHydrophobic ion pair
dc.titleNovel self-nanoemulsifying drug-delivery system enhances antileukemic properties of all- trans retinoic acid
dc.typeArtigo de periódico
local.citation.epage1486
local.citation.issue15
local.citation.spage1471
local.citation.volume15
local.description.resumoAll-trans retinoic acid (ATRA) shows erratic oral bioavailability when administered orally against leukemia, which can be solved through its incorporation in self-nanoemulsifying drug-delivery systems (SEDDS). The SEDDS developed contained a hydrophobic ion pair between benzathine (BZT) and ATRA and was enriched with tocotrienols by the input of a palm oil tocotrienol rich fraction (TRF) in its composition. Results: SEDDS-TRF-ATRA-BZT allowed the formation of emulsions with nanometric size that retained ATRA within their core after dispersion. Pharmacokinetic parameters after oral administration of SEDDS-TRF-ATRA-BZT in mice were improved compared with what was seen for an ATRA solution. Moreover, SEDDS-TRF-ATRA-BZT had improved activity against HL-60 cells compared with SEDDS without TRF.
local.identifier.orcidhttps://orcid.org/0000-0002-7360-8231
local.identifier.orcidhttps://orcid.org/0000-0002-0539-9052
local.identifier.orcidhttps://orcid.org/0000-0002-3905-3674
local.identifier.orcidhttps://orcid.org/0000-0003-2474-5536
local.identifier.orcidhttps://orcid.org/0000-0001-9467-154X
local.identifier.orcidhttps://orcid.org/0000-0002-1824-1983
local.identifier.orcidhttps://orcid.org/0000-0002-7898-210X
local.identifier.orcidhttps://orcid.org/0000-0001-5884-2567
local.identifier.orcidhttps://orcid.org/0000-0002-8703-4283
local.identifier.orcidhttps://orcid.org/0000-0001-8562-8689
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www-futuremedicine-com.ez27.periodicos.capes.gov.br/doi/epub/10.2217/nnm-2020-0061

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