GC-MS/MS versus LC-MS/MS for unambiguous identification of α and β-trenbolone in bovine urine

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dc.creatorAmanda Lemes Silveira
dc.creatorAdriana Ferreira Faria
dc.date.accessioned2022-10-24T17:03:35Z
dc.date.accessioned2025-09-08T23:25:59Z
dc.date.available2022-10-24T17:03:35Z
dc.date.issued2019
dc.identifier.doihttp://dx.doi.org/10.5935/sc.2019.013
dc.identifier.issn19844433
dc.identifier.urihttps://hdl.handle.net/1843/46539
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofScientia Chromatographica
dc.rightsAcesso Restrito
dc.subjectUrina
dc.subjectAnálise
dc.subjectCromatografia de gás
dc.subjectEspectrometria de massa
dc.subjectCromatografia líquida
dc.subjectBovino Saúde
dc.subject.otherBovine urine
dc.subject.otherGas chromatography tandem mass spectrometry
dc.subject.otherLiquid chromatography tandem mass spectrometry
dc.subject.otherMicrowave assisted derivatization
dc.subject.otherTrenbolone
dc.titleGC-MS/MS versus LC-MS/MS for unambiguous identification of α and β-trenbolone in bovine urine
dc.typeArtigo de periódico
local.citation.epage166
local.citation.issue4
local.citation.spage156
local.citation.volume11
local.description.resumoThis work involves the optimization of LC-MS/MS and GC-MS/MS methods for determination of α and β-trenbolone in bovine urine. The parameters recovery, repeatability and intermediate precision in both methods met the acceptance criteria of the Codex Alimentarius: recovery between 83.5-114% and repeatability and intermediate precision with RSD between 5.1-14.5% and 9.8-25.5% respectively, for concentrations higher than 1 μg kg−1. These methods were applied to the analyses of 5 real samples suspected of contamination. The analyses showed that derivatization with MSTFA/I2 followed by pure MSTFA, was an important tool to prevent false positive results. The use of microwave assisted derivatization reduced significantly the analysis time by GC-MS/MS.
local.identifier.orcidhttps://orcid.org/0000-0002-4678-861X
local.identifier.orcidhttps://orcid.org/0000-0002-7320-4907
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://iicweb.org/scientiachromatographica/v11n4doi10-5935-sc-2019-013en/

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