Lymphomas Affecting the Sublingual Glands: A Clinicopathological Study
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Resumo
Background Lymphomas afecting the sublingual glands are extremely rare and very few case reports are currently available.
Therefore, the aim of the current study is to describe the clinicopathological features of a series of lymphomas involving
the sublingual glands.
Methods Cases diagnosed in four pathology services were assessed and the formalin-fxed parafn-embedded tissue blocks
were retrieved for diagnosis confrmation. Clinical data were obtained from patients’ medical fles.
Results We obtained seven cases of lymphomas in the sublingual glands, representing two follicular lymphomas, two difuse
large B cell lymphomas not otherwise specifed (DLBCL NOS), two extranodal marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT lymphomas) and one mantle cell lymphoma (MCL). In all cases the tumor cells infltrated
the glandular parenchyma, although in two of them the neoplastic cells were located more superfcially and permeated the
glandular acini and ducts. Clinically, the tumors presented as asymptomatic nodules and two patients (afected by DLBCL
NOS and MCL) died, while the other fve patients remained alive at last follow-up.
Conclusion Lymphomas afecting the sublingual glands are usually of the mature B cell lineage, often represent low-grade
subtypes and may clinically resemble other more common lesions in the foor of the mouth like salivary gland tumors.
Abstract
Assunto
Odontologia, Linfoma
Palavras-chave
Linfoma, câncer de cabeça e pescoço, câncer bucal
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https://link.springer.com/article/10.1007/s12105-022-01489-8#citeas