Cylinder test to assess sensory-motor function in a mouse model of Parkinson's disease
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Resumo
Parkinson’s disease is a progressive neurodegenerative movement disorder that happens due to the loss of dopaminergic neurons in the substantia nigra. The deficiency of dopamine in the basal nuclei drives cardinal motor symptoms such as bradykinesia and hypokinesia. The current protocol describes the cylinder test, which is a relatively simple behavioral assessment that evaluates the motor deficits upon unilateral degeneration of the nigrostriatal pathway in experimental models of Parkinson’s disease. Since dopamine-depleted mice exhibit the preferential use of the forelimb ipsilateral to the lesion, here researchers perform the cylinder test to investigate the therapeutic effects of antiparkinsonian treatments on the performance of the contralateral (injured) limb.
Abstract
Assunto
Doença de Parkinson, Acidente vascular cerebral, Avaliação do comportamento, Comportamento
Palavras-chave
Cylinder test, Parkinson’s disease, Stroke, Motor system, Behavior
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https://bio-protocol.org/en/bpdetail?id=3337&type=0