Cylinder test to assess sensory-motor function in a mouse model of Parkinson's disease

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dc.creatorLuiz Alexandre Magno
dc.creatorMélcar Collodetti
dc.creatorHèlia Tenza-Ferrer
dc.creatorMarco Aurelio Romano Silva
dc.date.accessioned2025-02-06T21:58:50Z
dc.date.accessioned2025-09-08T23:51:02Z
dc.date.available2025-02-06T21:58:50Z
dc.date.issued2019-08-20
dc.format.mimetypepdf
dc.identifier.doi10.21769/bioprotoc.3337
dc.identifier.issn2331-8325
dc.identifier.urihttps://hdl.handle.net/1843/79740
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBio-protocol journal
dc.rightsAcesso Aberto
dc.subjectDoença de Parkinson
dc.subjectAcidente vascular cerebral
dc.subjectAvaliação do comportamento
dc.subjectComportamento
dc.subject.otherCylinder test
dc.subject.otherParkinson’s disease
dc.subject.otherStroke
dc.subject.otherMotor system
dc.subject.otherBehavior
dc.titleCylinder test to assess sensory-motor function in a mouse model of Parkinson's disease
dc.typeArtigo de periódico
local.citation.epage8
local.citation.issue16
local.citation.spage1
local.citation.volume9
local.description.resumoParkinson’s disease is a progressive neurodegenerative movement disorder that happens due to the loss of dopaminergic neurons in the substantia nigra. The deficiency of dopamine in the basal nuclei drives cardinal motor symptoms such as bradykinesia and hypokinesia. The current protocol describes the cylinder test, which is a relatively simple behavioral assessment that evaluates the motor deficits upon unilateral degeneration of the nigrostriatal pathway in experimental models of Parkinson’s disease. Since dopamine-depleted mice exhibit the preferential use of the forelimb ipsilateral to the lesion, here researchers perform the cylinder test to investigate the therapeutic effects of antiparkinsonian treatments on the performance of the contralateral (injured) limb.
local.identifier.orcidhttps://orcid.org/0000-0003-3693-1897
local.identifier.orcidhttps://orcid.org/0000-0003-1236-6424
local.identifier.orcidhttps://orcid.org/0000-0002-9175-5761
local.identifier.orcidhttps://orcid.org/0000-0002-6558-4639
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://bio-protocol.org/en/bpdetail?id=3337&type=0

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