Anti-inflammatory and antioxidant effects of the nanocomposite Fullerol decrease the severity of intestinal inflammation induced by gut ischemia and reperfusion
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Resumo
Intestinal ischemia is a vascular emergency that arises when blood flow to the intestine is compromised.
Reperfusion is necessary to restore intestinal function but might lead to local and systemic inflammatory responses and bacterial translocation, with consequent multiple organ dysfunction syndrome (MODS). During
reperfusion occurs production of reactive oxygen species. These species contribute to intestinal injury through
direct toxicity or activation of inflammatory pathways. Fullerol is a nanacomposite which has been shown to act
as reactive oxygen species and reactive nitrogen species (RNS) scavengers. Thus, our aim was to evaluate
whether Fullerol confer anti-inflammatory activity during intestinal ischemia and reperfusion (IIR). Intestinal
ischemia was induced by total occlusion of the superior mesenteric artery. Groups were treated with vehicle or
Fullerol 10 min before reperfusion. Mice were euthanized after 6 h of reperfusion, and small intestines were
collected for evaluation of plasma extravasation, leukocyte influx, cytokine production and histological damage.
Bacterial translocation to the peritoneal cavity and reactive oxygen and nitrogen species production by lamina
propria cells were also evaluated. Our results showed that treatment with Fullerol inhibited bacterial translocation to the peritoneal cavity, delayed and decreased the lethality rates and diminished neutrophil influx and
intestinal injury induced by IIR. Reduced severity of reperfusion injury in Fullerol-treated mice was associated
with blunted reactive oxygen and nitrogen species production in leukocytes isolated from gut lamina propria and
decreased production of pro-inflammatory mediators. Thus, the present study shows that Fullerol is a potential
therapy to treat inflammatory bowel disorders associated with bacterial translocation, such as IIR.
Abstract
Assunto
Isquemia intestinal, Reperfusão, Fulerol, Nanocompósitos
Palavras-chave
Intestinal ischemia and reperfusion, Fullerol, Nanocomposite, Reactive oxygen species
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https://www.sciencedirect.com/science/article/pii/S0014299921001370?via%3Dihub