Anti-inflammatory and antioxidant effects of the nanocomposite Fullerol decrease the severity of intestinal inflammation induced by gut ischemia and reperfusion

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dc.creatorRaquel Duque do Nascimento Arifa
dc.creatorMauro Martins Teixeira
dc.creatorCaio Tavares Fagundes
dc.creatorDaniele da Glória de Souza
dc.creatorTalles Prosperi de Paula
dc.creatorRenata Lacerda de Lima
dc.creatorCamila Bernardo de Brito
dc.creatorMaria Emília Rabelo Andrade
dc.creatorValbert Nascimento Cardoso
dc.creatorMauricio Veloso Brant Pinheiro
dc.creatorLuiz Orlando Ladeira
dc.creatorKlaus Wilhelm Heinrich Krambrock
dc.date.accessioned2025-02-24T18:34:19Z
dc.date.accessioned2025-09-09T00:51:15Z
dc.date.available2025-02-24T18:34:19Z
dc.date.issued2021
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)
dc.identifier.doihttps://doi.org/10.1016/j.ejphar.2021.173984
dc.identifier.issn0014-2999
dc.identifier.urihttps://hdl.handle.net/1843/80366
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofEuropean Journal of Pharmacology
dc.rightsAcesso Restrito
dc.subjectIsquemia intestinal
dc.subjectReperfusão
dc.subjectFulerol
dc.subjectNanocompósitos
dc.subject.otherIntestinal ischemia and reperfusion
dc.subject.otherFullerol
dc.subject.otherNanocomposite
dc.subject.otherReactive oxygen species
dc.titleAnti-inflammatory and antioxidant effects of the nanocomposite Fullerol decrease the severity of intestinal inflammation induced by gut ischemia and reperfusion
dc.typeArtigo de periódico
local.citation.epage9
local.citation.spage1
local.citation.volume898
local.description.resumoIntestinal ischemia is a vascular emergency that arises when blood flow to the intestine is compromised. Reperfusion is necessary to restore intestinal function but might lead to local and systemic inflammatory responses and bacterial translocation, with consequent multiple organ dysfunction syndrome (MODS). During reperfusion occurs production of reactive oxygen species. These species contribute to intestinal injury through direct toxicity or activation of inflammatory pathways. Fullerol is a nanacomposite which has been shown to act as reactive oxygen species and reactive nitrogen species (RNS) scavengers. Thus, our aim was to evaluate whether Fullerol confer anti-inflammatory activity during intestinal ischemia and reperfusion (IIR). Intestinal ischemia was induced by total occlusion of the superior mesenteric artery. Groups were treated with vehicle or Fullerol 10 min before reperfusion. Mice were euthanized after 6 h of reperfusion, and small intestines were collected for evaluation of plasma extravasation, leukocyte influx, cytokine production and histological damage. Bacterial translocation to the peritoneal cavity and reactive oxygen and nitrogen species production by lamina propria cells were also evaluated. Our results showed that treatment with Fullerol inhibited bacterial translocation to the peritoneal cavity, delayed and decreased the lethality rates and diminished neutrophil influx and intestinal injury induced by IIR. Reduced severity of reperfusion injury in Fullerol-treated mice was associated with blunted reactive oxygen and nitrogen species production in leukocytes isolated from gut lamina propria and decreased production of pro-inflammatory mediators. Thus, the present study shows that Fullerol is a potential therapy to treat inflammatory bowel disorders associated with bacterial translocation, such as IIR.
local.identifier.orcidhttps://orcid.org/0000-0003-0888-2282
local.identifier.orcidhttps://orcid.org/0000-0002-6944-3008
local.identifier.orcidhttps://orcid.org/0000-0002-6747-5233
local.identifier.orcidhttps://orcid.org/0000-0002-7478-5934
local.identifier.orcidhttps://orcid.org/0000-0003-3120-5183
local.identifier.orcidhttps://orcid.org/0000-0002-4571-7238
local.identifier.orcidhttps://orcid.org/0000-0001-7597-9602
local.identifier.orcidhttps://orcid.org/0000-0001-5722-6260
local.identifier.orcidhttps://orcid.org/0000-0002-4935-6070
local.identifier.orcidhttps://orcid.org/0000-0002-7562-0285
local.publisher.countryBrasil
local.publisher.departmentENG - DEPARTAMENTO DE ENGENHARIA QUÍMICA
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0014299921001370?via%3Dihub

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