Prospective randomised clinical trial using autogenous bone or beta-tricalcium phosphate in maxillary sinus lifting: histological and tomographic results
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Universidade Federal de Minas Gerais
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Objectives: The aim of this study was to analyse the use of the
beta-tricalcium phosphate (-TCP) ChronOS® and autogenous
bone (AB) in maxillary sinus floor augmentation by compar
ing computed tomography (CT), histological, histometric and
immunohistochemical analysis.
Methods: 12 consecutive patients underwent bilateral maxillary
sinus grafting. One side of each patient was augmented with pure-TCP and the other sinus was augmented with pure autogenous
bone. Patients had their sinus scanned for computed tomography
(CT)seven and 180 day safter surgery for quantitative comparative
analysis of residual volume after graft resorption and remodeling.
Prior to implant placement, grafted material was collected from each sinus using a drilling mill for histological and histochemical
analysis.
Findings: CT volumetric analysis revealed no statistically signif
icant difference between groups. Histological analysis revealed
absorbing granules of-TCP being substituted by mature bone.
Histomorphometric analysis showed the presence of 51.58%
of newly formed bone in the-TCP group and 40.97% in
the AB group. There was no statistical difference between the
groups. Immunohistochemical evaluated the presence of osteocal
cin, Runt-related transcription factor2(RUNX2),tartrate-resistant
acidic phosphatase(TRAP)and vascular end endothelial growth factor
(VEGF). Osteocalcin and VEGF were expressed in both groups
with similar intensity. TRAP showed a low expression in both
groups. RUNX2 was observed only in AB group.
Conclusions:Autogenous bone has superior osteoinductive prop
erties. ChronOS® isa biocompatible and osteoconductive material
with similar clinical results to the autogenous bone in this proposed
model, even without osteoinductive properties.
Abstract
Assunto
Tartrate-resistant acid phosphatase, Mouth floor, Maxillary sinus, Bone and bones, Residual volume, Immunohistochemistry, Osteocalcin
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https://www.ijoms.com/article/S0901-5027(17)30958-X/fulltext