Edaravone inhibits the production of reactive oxygen species in phagocytosis- and pkc-stimulated granulocytes from multiple sclerosis patients edaravone modulate oxidative stress in multiple sclerosis

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dc.creatorPedro Henrique Villar-Delfino
dc.creatorNathália Augusta Oliveira Gomes
dc.creatorPaulo Pereira Christo
dc.creatorJosé Augusto Nogueira-Machado
dc.creatorCaroline Maria Oliveira Volpe
dc.date.accessioned2023-12-07T21:39:07Z
dc.date.accessioned2025-09-08T22:49:43Z
dc.date.available2023-12-07T21:39:07Z
dc.date.issued2022
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1177/11795735221092524
dc.identifier.issn1179-5735
dc.identifier.urihttps://hdl.handle.net/1843/61856
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Central Nervous System Disease
dc.rightsAcesso Aberto
dc.subjectEdaravone
dc.subjectEsclerose Múltipla
dc.subjectEstresse Oxidativo
dc.subject.otherMultiple Sclerosis
dc.subject.otherEdaravone
dc.subject.otherOxidative stress modulation
dc.titleEdaravone inhibits the production of reactive oxygen species in phagocytosis- and pkc-stimulated granulocytes from multiple sclerosis patients edaravone modulate oxidative stress in multiple sclerosis
dc.typeArtigo de periódico
local.citation.epage7
local.citation.spage1
local.citation.volume14
local.description.resumoBACKGROUND: Oxidative stress is associated with the pathogenesis of MS. Edaravone (EDV) has been proposed as a therapeutic resource for central nervous system diseases, and it was effective in reducing oxidative stress. However, the antioxidant mechanisms of EDV are poorly studied. OBJECTIVE: This study aimed to evaluate the effects of EDV on resting, phagocytosis, and PKC-activated granulocytes derived from MS patients and a healthy control group. METHODS: The effects of EDV on ROS production in phagocytosis (ROS production in the presence of opsonized particles) and PKC-stimulated granulocytes were evaluated in a luminol-dependent chemiluminescence method. Calphostin C was used in some experiments to compare with those of EDV. RESULTS: EDV inhibited ROS production in phagocytosis of opsonized particles and PKC-stimulated granulocytes from MS patients and healthy control group. In the presence of calphostin C, the inhibition of ROS production was similar to that observed with EDV. CONCLUSION: These findings suggest the involvement of EDV on the ROS-PKC-NOX signaling pathways modulating oxidative stress in MS. EDV represents a promising treatment option to control oxidative innate immune response for MS. KEYWORDS: edaravone, multiple sclerosis, innate immunity, reactive oxygen species, phagocytosis, protein kinase C.
local.identifier.orcidhttps://orcid.org/0000-0003-1224-5243
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://journals.sagepub.com/doi/10.1177/11795735221092524

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