Cohort profile update: the main and new findings from the sami-trop chagas cohort
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Universidade Federal de Minas Gerais
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Cohort profile update: the main and new findings from the sami-trop chagas cohort
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Resumo
The SaMi-Trop project is a cohort study conducted in 21 municipalities of endemic
areas of Chagas disease, including 1,959 patients with chronic Chagas cardiomyopathy. In
this article we updated the results of the project, adding information from the second cohort
visit. Trypanosoma cruzi-seropositive patients were enrolled from the primary care Telehealth
service in Minas Gerais State, Brazil. The eligibility criterium for the second visit was the
participation in the baseline evaluation. Of 1,959 participants at the baseline assessment,
1,585 (79.9%) returned after two years for the second evaluation. The mortality rate was
6.7%, but varied from 0.9% to 18.2% when it was stratified by certain clinical characteristics.
A lower age-adjusted NT-Pro-BNP level (less than 300) and a prior benznidazole treatment
were associated with lower mortality. There was an improvement in most quality of life
domain scores. Participants have also reported fewer signs and symptoms and greater use
of medication. The second follow-up visit will be complete in Oct 2021.
Abstract
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Medicina
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Doença de Chagas
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Endereço externo
http://https://doi.org/10.1590/s1678-9946202163075