Cohort profile update: the main and new findings from the sami-trop chagas cohort

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dc.creatorClaudia di Lorenzooliveira
dc.creatorLewis f. Buss
dc.creatorDesiree Sant?ana Haikal
dc.creatorEdecio Cunha Neto
dc.creatorAntonio Luiz Pinho Ribeiro
dc.creatorEster Cerdeira Sabino
dc.creatorClareci Silva Cardoso
dc.creatorNayara Ragi Baldoni
dc.creatorLarissa Natany
dc.creatorAriela Mota Ferreira
dc.creatorLea Campos de Oliveira
dc.creatorMaria do Carmo Pereira Nunes
dc.creatorNayara Dornela Quintino
dc.creatorAna Luiza Bierrenbach
dc.date.accessioned2024-01-16T13:11:56Z
dc.date.accessioned2025-09-09T00:01:04Z
dc.date.available2024-01-16T13:11:56Z
dc.date.issued2021
dc.identifier.doi10.1590/s1678-9946202163075
dc.identifier.issn16789946
dc.identifier.urihttps://hdl.handle.net/1843/62855
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofRevista do Instituto de Medicina Tropical de São Paulo
dc.rightsAcesso Aberto
dc.subjectMedicina
dc.subject.otherDoença de Chagas
dc.titleCohort profile update: the main and new findings from the sami-trop chagas cohort
dc.title.alternativeCohort profile update: the main and new findings from the sami-trop chagas cohort
dc.typeArtigo de periódico
local.citation.spagee63
local.citation.volume63
local.description.resumoThe SaMi-Trop project is a cohort study conducted in 21 municipalities of endemic areas of Chagas disease, including 1,959 patients with chronic Chagas cardiomyopathy. In this article we updated the results of the project, adding information from the second cohort visit. Trypanosoma cruzi-seropositive patients were enrolled from the primary care Telehealth service in Minas Gerais State, Brazil. The eligibility criterium for the second visit was the participation in the baseline evaluation. Of 1,959 participants at the baseline assessment, 1,585 (79.9%) returned after two years for the second evaluation. The mortality rate was 6.7%, but varied from 0.9% to 18.2% when it was stratified by certain clinical characteristics. A lower age-adjusted NT-Pro-BNP level (less than 300) and a prior benznidazole treatment were associated with lower mortality. There was an improvement in most quality of life domain scores. Participants have also reported fewer signs and symptoms and greater use of medication. The second follow-up visit will be complete in Oct 2021.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttp://https://doi.org/10.1590/s1678-9946202163075

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