Association between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
BACKGROUND Dengue is an arthropod-borne viral disease with a majority of asymptomatic individuals and clinical manifestations varying from mild fever to severe and potentially lethal forms. An increasing number of genetic studies have outlined the association between host genetic variations and dengue severity. Genes associated to viral recognition and entry, as well as those encoding mediators of the immune response against infection are strong candidates for association studies.
OBJECTIVES The aim of this study was to investigate the association between MBL2, CLEC5A, ITGB3 and CCR5 genes and
dengue severity in children.
METHODS A matched case-control study was conducted and 19 single nucleotide polymorphisms (SNPs) were investigated.
FINDINGS No associations were observed in single SNP analysis. However, when MBL2 SNPs were combined in haplotypes, the
allele rs7095891G/rs1800450C/ rs1800451C/rs4935047A/rs930509G/rs2120131G/rs2099902C was significantly associated to risk
of severe dengue under α = 0.05 (aOR = 4.02; p = 0.02). A second haplotype carrying rs4935047G and rs7095891G alleles was
also associated to risk (aOR = 1.91; p = 0.04).
MAIN CONCLUSIONS This is the first study to demonstrate the association between MBL2 haplotypes and dengue severity
in Brazilians including adjustment for genetic ancestry. These results reinforce the role of mannose binding lectin in immune
response to DENV.
Abstract
Assunto
Genética, Vírus da dengue, Pesquisa imunológica
Palavras-chave
Dengue, Polymorphisms, MBL2, CCR5, ITGB3, CLEC5A
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Endereço externo
https://www.arca.fiocruz.br/handle/icict/33446