Association between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil

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dc.creatorAlice Maria de Magalhães Ornelas
dc.creatorCaroline Xavier-de-Carvalho
dc.creatorLucia Elena Alvarado-Arnez
dc.creatorMarcelo Ribeiro-Alves
dc.creatorÁtila Duque Rossi
dc.creatorAmilcar Tanuri
dc.creatorRenato Santana de Aguiar
dc.creatorMilton Ozório Moraes
dc.creatorCynthia Chester Cardoso
dc.date.accessioned2025-01-21T21:08:26Z
dc.date.accessioned2025-09-09T00:16:57Z
dc.date.available2025-01-21T21:08:26Z
dc.date.issued2019
dc.format.mimetypepdf
dc.identifier.issn0074-0276
dc.identifier.urihttps://hdl.handle.net/1843/79382
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMemórias do Instituto Oswaldo Cruz
dc.rightsAcesso Aberto
dc.subjectGenética
dc.subjectVírus da dengue
dc.subjectPesquisa imunológica
dc.subject.otherDengue
dc.subject.otherPolymorphisms
dc.subject.otherMBL2
dc.subject.otherCCR5
dc.subject.otherITGB3
dc.subject.otherCLEC5A
dc.titleAssociation between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil
dc.typeArtigo de periódico
local.citation.epage9
local.citation.spage1
local.citation.volume114
local.description.resumoBACKGROUND Dengue is an arthropod-borne viral disease with a majority of asymptomatic individuals and clinical manifestations varying from mild fever to severe and potentially lethal forms. An increasing number of genetic studies have outlined the association between host genetic variations and dengue severity. Genes associated to viral recognition and entry, as well as those encoding mediators of the immune response against infection are strong candidates for association studies. OBJECTIVES The aim of this study was to investigate the association between MBL2, CLEC5A, ITGB3 and CCR5 genes and dengue severity in children. METHODS A matched case-control study was conducted and 19 single nucleotide polymorphisms (SNPs) were investigated. FINDINGS No associations were observed in single SNP analysis. However, when MBL2 SNPs were combined in haplotypes, the allele rs7095891G/rs1800450C/ rs1800451C/rs4935047A/rs930509G/rs2120131G/rs2099902C was significantly associated to risk of severe dengue under α = 0.05 (aOR = 4.02; p = 0.02). A second haplotype carrying rs4935047G and rs7095891G alleles was also associated to risk (aOR = 1.91; p = 0.04). MAIN CONCLUSIONS This is the first study to demonstrate the association between MBL2 haplotypes and dengue severity in Brazilians including adjustment for genetic ancestry. These results reinforce the role of mannose binding lectin in immune response to DENV.
local.identifier.orcidhttps://orcid.org/0000-0002-3537-6361
local.identifier.orcidhttps://orcid.org/0000-0002-8663-3364
local.identifier.orcidhttps://orcid.org/0000-0001-6235-8807
local.identifier.orcidhttps://orcid.org/0000-0003-2653-0037
local.publisher.countryBrasil
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.initialsUFMG
local.url.externahttps://www.arca.fiocruz.br/handle/icict/33446

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