Mesoscopic model confirms strong base pair metal mediated bonding for T–Hg2+ –T and weaker for C–Ag+–C
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Resumo
Metal mediated DNA are mismatches where a metal ion bridges the base pairs and are of interest for biosensors.
Here, we study T–Hg2+–T, which is known to be stabilized by base pair metal mediated bonds, and C–Ag+–C
whose stabilization mechanism is less well understood. We use a mesoscopic model and published melting
temperatures of sequences containing CC or TT mismatches in the presence of the metal ions. For T–Hg2+–T
we obtain a strong base pair bond potential and moderate one for C–Ag+–C, only one stacking potential for
each configuration is stronger than usual.
Abstract
Assunto
Biofísica, DNA, Hidrogênio
Palavras-chave
Metal-mediated DNA, Metallo-base-pair, Peyrard–Bishop DNA model, DNA stability, Hydrogen bonds, Stacking interaction
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https://www.sciencedirect.com/science/article/pii/S0009261422005139