Further evidence of accelerated aging in bipolar disorder: focus on gdf-15
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Universidade Federal de Minas Gerais
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BACKGROUND: Bipolar disorder (BD) is a mood disorder associated with cardiovascular and metabolic diseases and premature aging. Growth differentiation factor 15 (GDF-15) has emerged as a biomarker for cardiovascular risk and aging. Our aim was to compare plasma levels of GDF-15 between BD patients and controls, and to evaluate whether they were associated with clinical parameters. METHODS: Forty-six patients with type I BD (23 in euthymia and 23 in mania) and 33 healthy controls were recruited for this study. Plasma levels of GDF-15 were measured by immunoassay. RESULTS: The levels of GDF-15 were significantly higher (p < 0.001) in patients with BD in comparison with controls. In patients, GDF-15 levels correlated with age (rho = 0.434; p = 0.003) and illness
duration (rho = 0.502; p = 0.001). CONCLUSION: Our findings corroborate the view that BD is an illness associated with accelerated aging.
Abstract
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Transtorno Bipolar, Fator 15 de Diferenciação de Crescimento, Envelhecimento
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Bipolar disorder, Growth Differentiation Factor 15, Aging
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https://www.degruyter.com/document/doi/10.1515/tnsci-2018-0004/html