Further evidence of accelerated aging in bipolar disorder: focus on gdf-15

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dc.creatorFangyang
dc.creatorIzabela Guimarães Barbosa
dc.creatorErica l. Vieira
dc.creatorMoises e. Bauer
dc.creatorNatalia p. Rocha
dc.creatorAntonio l. Teixeira
dc.date.accessioned2023-07-17T20:55:50Z
dc.date.accessioned2025-09-09T01:24:38Z
dc.date.available2023-07-17T20:55:50Z
dc.date.issued2018-03-09
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1515/tnsci-2018-0004
dc.identifier.issn20816936
dc.identifier.urihttps://hdl.handle.net/1843/56522
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofTranslational Neuroscience
dc.rightsAcesso Aberto
dc.subjectTranstorno Bipolar
dc.subjectFator 15 de Diferenciação de Crescimento
dc.subjectEnvelhecimento
dc.subject.otherBipolar disorder
dc.subject.otherGrowth Differentiation Factor 15
dc.subject.otherAging
dc.titleFurther evidence of accelerated aging in bipolar disorder: focus on gdf-15
dc.typeArtigo de periódico
local.citation.epage21
local.citation.issue1
local.citation.spage17
local.citation.volume9
local.description.resumoBACKGROUND: Bipolar disorder (BD) is a mood disorder associated with cardiovascular and metabolic diseases and premature aging. Growth differentiation factor 15 (GDF-15) has emerged as a biomarker for cardiovascular risk and aging. Our aim was to compare plasma levels of GDF-15 between BD patients and controls, and to evaluate whether they were associated with clinical parameters. METHODS: Forty-six patients with type I BD (23 in euthymia and 23 in mania) and 33 healthy controls were recruited for this study. Plasma levels of GDF-15 were measured by immunoassay. RESULTS: The levels of GDF-15 were significantly higher (p < 0.001) in patients with BD in comparison with controls. In patients, GDF-15 levels correlated with age (rho = 0.434; p = 0.003) and illness duration (rho = 0.502; p = 0.001). CONCLUSION: Our findings corroborate the view that BD is an illness associated with accelerated aging.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://www.degruyter.com/document/doi/10.1515/tnsci-2018-0004/html

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