Alterações hematológicas induzidas por medicamentos

Abstract

A number of drugs has been associated to adverse reactions, namely, blood dyscrasias. Besides, significant alterations in laboratory analysis interfering in the clinical diagnosis have also been associated to certain drugs use. Adverse drugs reactions (ADR) can be defined as a harmful and non intentional effect due to drugs use in usual doses taken for prophylaxis, diagnosis and treatment. By other side, blood dyscrasias can be defined as any alteration in the blood components and may include neutr openia, agranulocytosis, thrombocytopenia or leukopenia. Diferent groups of drugs as oral anticoagulants, antipsychotics, chemotherapics, antibiotics, analgesics, and even alternative drugs may induce blood dyscrasias, among others. The understanding about drugs use and the possible ADR, such as hematologic alterations, is very important in order to adopt strategies for prevention and for their early detection and/or their management avoiding clinical complications. It is known that many aspects are important for the ADR triggering, such as demographic characteristics, socioeconomic status, habits and life style, comorbidities, etc. Face to this knowledge and to the scarcity of studies focusing this issue in the country, it would be strongly desirable that new and wide approaches may be addressed in order to acquire new insights about this important question, essential aspect for introducing new strategies for ADR management. The present study has as a general aim to review adverse effects to drugs more commonlydescribed, due to the use of certain drugs on the hematopoetic system, as well as nterferences on the results of laboratory analysis.