Nestin and neuron-glial antigen 2 transgenes unveil progenitor units in murine salivary glands

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dc.creatorIsabella Bittencourt do Valle
dc.creatorNatália Aparecida Gomes
dc.creatorIvana Márcia Alves Diniz
dc.creatorJosé Alcides Almeida de Arruda
dc.creatorTatiana Fernandes Araújo Almeida
dc.creatorMariana Souza Santos
dc.creatorAlexander Birbrair
dc.creatorSandra Ventorin Von Zeidler
dc.creatorTarcília Aparecida da Silva
dc.date.accessioned2025-05-09T21:27:23Z
dc.date.accessioned2025-09-08T22:48:31Z
dc.date.available2025-05-09T21:27:23Z
dc.date.issued2022-02
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.archoralbio.2021.105344
dc.identifier.issn1879-1506
dc.identifier.urihttps://hdl.handle.net/1843/82193
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArchives of Oral Biology
dc.rightsAcesso Restrito
dc.subjectNestin
dc.subjectSalivary glands
dc.subjectParotid gland
dc.subjectStem cells
dc.subjectSublingual gland
dc.subjectSubmandibular gland.
dc.subjectSubmandibular gland
dc.subjectHomeostasis
dc.subject.otherNestin
dc.subject.otherNeuron-glial antigen 2
dc.subject.otherSalivary gland
dc.subject.otherParotid gland
dc.subject.otherStem cell
dc.subject.otherSublingual gland
dc.subject.otherSubmandibular gland
dc.titleNestin and neuron-glial antigen 2 transgenes unveil progenitor units in murine salivary glands
dc.typeArtigo de periódico
local.citation.spage105344
local.citation.volume134
local.description.resumoObjective: Undifferentiated cells play pivotal roles in sustaining tissue homeostasis during physiological turnovers and after tissue impairment. Nestin and Neuron-glial antigen 2 (NG2) are markers frequently deployed to distinguish progenitor populations. In the salivary gland scenario, these markers remain largely unknown. Particularly for a double-labeled group of progenitor cells (NG2+Nestin+), their phenotype and distribution have never been explored in freshly isolated tissues. Herein, we analyzed a subset of plastic cells that express Nestin and NG2 near the ducts and in the periacinar region of the major salivary glands of murine samples. Design: The major salivary glands tissues of Nestin-GFP/NG2-DsRed mice were analyzed under a fluorescence microscope. The cells marked by GFP and DsRed were counted in the merged image component of random representative images obtained for each gland sample at × 20 magnification. Results: In the parotid, submandibular, and sublingual glands, the population of cells exclusively expressing Nestin was more abundant. There was a predominance of Nestin, NG2, and double-labeled cells in the submandibular gland compared to the parotid gland, mainly near the ductal system. Of note, the sublingual and parotid glands had similar populations of Nestin+ and NG2+, especially in acini, and some positive cells were observed surrounding ducts.
local.identifier.orcidhttps://orcid.org/0000-0002-3221-3057
local.identifier.orcidhttps://orcid.org/0000-0001-6316-4713
local.identifier.orcidhttps://orcid.org/0000-0003-4261-0037
local.identifier.orcidhttps://orcid.org/0000-0002-6599-3950
local.identifier.orcidhttps://orcid.org/0000-0002-3216-5649
local.identifier.orcidhttps://orcid.org/0000-0003-1015-2561
local.identifier.orcidhttps://orcid.org/0000-0002-8897-5747
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0003996921003071?via%3Dihub

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