Drug enhancement, synergism and antifungal activity of miconazole associated polygodial against Candida albicans
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
Miconazole has low toxicity, however, there is a high incidence resistance of Candida sp. In the
search for new drugs or improve existing ones, the originating products of medicinal plants has
been the target of constant studies. The aim of this work was to verifyin vitrosynergism and
antifungal activity of miconazole associated with poligodial. Miconazole (MCZ) and Poligodial
(P) were dissolved in dimethylsulfoxide (DMSO) 1% done successive dilutions of each product
ranging from 25mg to 0,19mg/mL (Polygodial)(10-1 to 10-9mg / ml); 14mg to 0,10mg/mL
(miconazole). Antifungal test were based by CLSI diffusion agar against C. albicans (ATCC
18804), C. albicans (LMB01) and C. albicans (LMB02), C. tropicalis (ATCC 18807), C.
lusitaniae (ATCC 42720), C. krusei (ATCC 20405). The results had shown all compounds that
were effective in inhibiting Candida species. However, the zones of inhibition in agar diffusion
test were higher for Miconazole (16,83mm) and Polygodial (15,16mm) while the MIX showed
lower inhibition zones (14,43mm) when compared with controls. MIX was more effective in
MIC test, and lowest concentration were at 10-6 dilution (0,60mg / ml) compared to MCZ and P
controls.
Abstract
Assunto
Miconazole, Candida albicans, Contact inhibition, Candida tropicalis, Pharmaceutical preparations, Antifungal agents, Drug synergism
Palavras-chave
Candida sp, Miconazole, Polygodial, Antifungal activity, MIC
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Curso
Endereço externo
https://www.granthaalayahpublication.org/journals/granthaalayah/article/view/IJRG17_A11_782