Drug enhancement, synergism and antifungal activity of miconazole associated polygodial against Candida albicans

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dc.creatorVagner Rodrigues Santos
dc.creatorLivia Samara Franciele de Souza Pinto
dc.creatorBruno Cesar Borges Araujo Ribeiro
dc.creatorIsao Kubo
dc.date.accessioned2025-06-24T22:21:10Z
dc.date.accessioned2025-09-08T22:58:27Z
dc.date.available2025-06-24T22:21:10Z
dc.date.issued2017-11-30
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.29121/granthaalayah.v5.i11.2017.2332
dc.identifier.issn2350-0530
dc.identifier.urihttps://hdl.handle.net/1843/83115
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Journal of Research - Granthaalayah
dc.rightsAcesso Aberto
dc.subjectMiconazole
dc.subjectCandida albicans
dc.subjectContact inhibition
dc.subjectCandida tropicalis
dc.subjectPharmaceutical preparations
dc.subjectAntifungal agents
dc.subjectDrug synergism
dc.subject.otherCandida sp
dc.subject.otherMiconazole
dc.subject.otherPolygodial
dc.subject.otherAntifungal activity
dc.subject.otherMIC
dc.titleDrug enhancement, synergism and antifungal activity of miconazole associated polygodial against Candida albicans
dc.typeArtigo de periódico
local.citation.epage101
local.citation.issue11
local.citation.spage95
local.citation.volume5
local.description.resumoMiconazole has low toxicity, however, there is a high incidence resistance of Candida sp. In the search for new drugs or improve existing ones, the originating products of medicinal plants has been the target of constant studies. The aim of this work was to verifyin vitrosynergism and antifungal activity of miconazole associated with poligodial. Miconazole (MCZ) and Poligodial (P) were dissolved in dimethylsulfoxide (DMSO) 1% done successive dilutions of each product ranging from 25mg to 0,19mg/mL (Polygodial)(10-1 to 10-9mg / ml); 14mg to 0,10mg/mL (miconazole). Antifungal test were based by CLSI diffusion agar against C. albicans (ATCC 18804), C. albicans (LMB01) and C. albicans (LMB02), C. tropicalis (ATCC 18807), C. lusitaniae (ATCC 42720), C. krusei (ATCC 20405). The results had shown all compounds that were effective in inhibiting Candida species. However, the zones of inhibition in agar diffusion test were higher for Miconazole (16,83mm) and Polygodial (15,16mm) while the MIX showed lower inhibition zones (14,43mm) when compared with controls. MIX was more effective in MIC test, and lowest concentration were at 10-6 dilution (0,60mg / ml) compared to MCZ and P controls.
local.identifier.orcidhttps://orcid.org/0000-0002-5370-4867
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.granthaalayahpublication.org/journals/granthaalayah/article/view/IJRG17_A11_782

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