An innovative, simple, fast, and less toxic high-performance liquid chromatographic method for determination of prednisone in capsules

Página do item simplificado
dc.creatorPedro Henrique Reis da Silva
dc.creatorPaula Cristina Rezende Enéas
dc.creatorChristian Fernandes
dc.creatorGerson Antônio Pianetti
dc.date.accessioned2022-04-07T20:34:39Z
dc.date.accessioned2025-09-09T01:24:35Z
dc.date.available2022-04-07T20:34:39Z
dc.date.issued2017
dc.identifier.doihttps://doi.org/10.1590/s2175-97902017000216064
dc.identifier.issn2175-9790
dc.identifier.urihttps://hdl.handle.net/1843/40900
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciences
dc.rightsAcesso Aberto
dc.subjectQuímica
dc.subjectPrednisona
dc.subjectCápsulas (Farmácia)
dc.subject.otherPrednisone
dc.subject.otherCapsules
dc.subject.otherHigh performance liquid chromatography/validation
dc.subject.otherLinearity assessment
dc.titleAn innovative, simple, fast, and less toxic high-performance liquid chromatographic method for determination of prednisone in capsules
dc.title.alternativeAn innovative, simple, fast, and less toxic high-performance liquid chromatographic method for determination of prednisone in capsules
dc.typeArtigo de periódico
local.citation.epage7
local.citation.issue2
local.citation.spage1
local.citation.volume53
local.description.resumoPrednisone is an anti-inflammatory steroid drug widely used in clinical practice. However, no highperformance liquid chromatographic (HPLC) method has been described in the literature for the determination of prednisone in capsules until now. Thus, an HPLC method was developed using a C18 (250x4.0, 5 µm) column, with methanol:water (70:30) as mobile phase at a flow rate of 1 mL/min and detection at 240 nm. The developed method was validated following current Brazilian legislation. Additionally, linearity was assessed by evaluating the assumptions of normality, homoscedasticity, and independency of residuals, and the fit to the linear model. The method showed linearity (r2 >0.99) over the range of 14.0-26.0 µg/mL, selectivity, precision (RSD<2.0%), robustness, and accuracy (average recovery of 100.05%). The chromatographic procedure was applied for assay and uniformity content determination of three different batches of prednisone capsules, showing to be suitable for their quality control
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/bjps/a/9WrhFmD4HpVPHYKqWwJKGpq/?lang=en

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Braz. J. Pharm. Sci_ An innovative, simple, fast, and less toxic high-performance liquid chromatographic method for determination of prednisone in capsules.pdf
Tamanho:
431.5 KB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG