On the application of 3d metals for C-H activation toward bioactive compounds: the key step for the synthesis of silver bullets
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
Several valuable biologically active molecules can be obtained through C–H activation processes. However, the use of expensive and not readily accessible catalysts complicates the process of pharmacological application of these compounds. A plausible way to overcome this issue is developing and using cheaper, more accessible, and equally effective catalysts. First-row transition (3d) metals have shown to be important catalysts in this matter. This review summarizes the use of 3d metal catalysts in C–H activation processes to obtain potentially (or proved) biologically active compounds.
Abstract
Assunto
Compostos bioativos, Síntese orgânica, Agentes antivirais, Agentes antineoplásicos, Agentes antiinfecciosos, Quinoleina, Química farmacêutica
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Bioactive compounds, C–H activation, 3d metals, Drugs, Medicinal chemistry
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https://www.beilstein-journals.org/bjoc/articles/17/126