Prevention of bone infection after open fracture using a chitosan with ciprofloxacin implant in animal model
Carregando...
Data
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Minas Gerais
Descrição
Tipo
Artigo de periódico
Título alternativo
Primeiro orientador
Membros da banca
Resumo
Purpose
To evaluate different concentrations of ciprofloxacin to prevent infection after open fracture contaminated with S. aureus in rats using absorbable local delivery system.
Methods
Fifty-two Wistar rats were assigned to six groups. After 4 weeks, all animals underwent 99mTc-ceftizoxima scintigraphy evaluation, callus formation measurement and histological analysis. ANOVA, t-Student and Kruskal Wallis were used for quantitative variables statistical analysis, whereas qui square and exact Fisher were used for qualitative variables.
Results
Treatment using 25% and 50% of ciprofloxacin incorporated at the fracture fixation device were effective in preventing bone infection compared to control group (p<0.05). Chitosan were not effective in preventing bone infection when used alone compared to control group (p>0.05). Histological findings demonstrated bone-healing delay with 50% of ciprofloxacin. No difference in callus formation were observed (p>0.05).
Conclusion
Local delivery treatment for contaminated open fracture using chitosan with ciprofloxacin is effective above 25%.
Abstract
Assunto
Infecção óssea, Quitosana, Ciprofloxacina
Palavras-chave
Osteitis, Chitosan, Ciprofloxacin, Fractures, Open, Rats
Citação
Curso
Endereço externo
https://www.scielo.br/j/acb/a/sKyMmtWm8F4dSvSpcg753Pd/?lang=en